The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes?
The increased incidence of cancer in children and adolescents registered in Italy in the last few decades is one of the highest amongst Western countries. The causes are difficult to identify, but recent daily news and some epidemiological surveys, such as the ‘Sentieri’ study, suggest that environ...
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| Format: | Article |
| Language: | English |
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Edizioni FS
2016-03-01
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| Series: | Journal of Health and Social Sciences |
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| Online Access: | http://journalhss.com/wp-content/uploads/JHHS1129-36.pdf |
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| author | Ruggero Ridolfi |
| author_facet | Ruggero Ridolfi |
| author_sort | Ruggero Ridolfi |
| collection | DOAJ |
| description | The increased incidence of cancer in children and adolescents registered in Italy in the last few decades is one of the highest amongst Western countries. The causes are difficult to identify, but
recent daily news and some epidemiological surveys, such as the ‘Sentieri’ study, suggest that environmental pollution has an important role. In the past 20 years, epigenetic studies have described how the changes induced by the cell microenvironment on the non-coding parts of the genome can heavily influence gene function, contributing to the carcinogenesis process. Connecting links amongst the external environment, cellular microenvironment and functional epigenetic and genetic mutations promote carcinogenesis. Today, the whole genome sequencing techniques for human cancers can help to formulate a map of mutational signatures in individual tumours, and a list of mutational fingerprints showing exposure to specific environmental mutagens is being developed. Determining the ethical, legal and economic consequences of known cancer causative agents in young people will be a crucial step for a serious reconsideration of primary prevention. |
| format | Article |
| id | doaj-art-819ff2eaacc94c248ecdb5d05eedda98 |
| institution | Kabale University |
| issn | 2499-2240 2499-5886 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Edizioni FS |
| record_format | Article |
| series | Journal of Health and Social Sciences |
| spelling | doaj-art-819ff2eaacc94c248ecdb5d05eedda982025-01-18T18:20:29ZengEdizioni FSJournal of Health and Social Sciences2499-22402499-58862016-03-0111293610.19204/2016/thhg5The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes?Ruggero Ridolfi0International Society of Doctors for the Environment (ISDE). ISDE Forlì Cesena, Italy. Honorary President of Italian Melanoma Intergroup (IMI)The increased incidence of cancer in children and adolescents registered in Italy in the last few decades is one of the highest amongst Western countries. The causes are difficult to identify, but recent daily news and some epidemiological surveys, such as the ‘Sentieri’ study, suggest that environmental pollution has an important role. In the past 20 years, epigenetic studies have described how the changes induced by the cell microenvironment on the non-coding parts of the genome can heavily influence gene function, contributing to the carcinogenesis process. Connecting links amongst the external environment, cellular microenvironment and functional epigenetic and genetic mutations promote carcinogenesis. Today, the whole genome sequencing techniques for human cancers can help to formulate a map of mutational signatures in individual tumours, and a list of mutational fingerprints showing exposure to specific environmental mutagens is being developed. Determining the ethical, legal and economic consequences of known cancer causative agents in young people will be a crucial step for a serious reconsideration of primary prevention.http://journalhss.com/wp-content/uploads/JHHS1129-36.pdfneoplasms; primary prevention; carcinogensenvironmental; epigenomics; DNA mutational analysis |
| spellingShingle | Ruggero Ridolfi The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? Journal of Health and Social Sciences neoplasms; primary prevention; carcinogens environmental; epigenomics; DNA mutational analysis |
| title | The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? |
| title_full | The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? |
| title_fullStr | The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? |
| title_full_unstemmed | The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? |
| title_short | The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? |
| title_sort | high cancer incidence in young people in italy do genetic signatures reveal their environmental causes |
| topic | neoplasms; primary prevention; carcinogens environmental; epigenomics; DNA mutational analysis |
| url | http://journalhss.com/wp-content/uploads/JHHS1129-36.pdf |
| work_keys_str_mv | AT ruggeroridolfi thehighcancerincidenceinyoungpeopleinitalydogeneticsignaturesrevealtheirenvironmentalcauses AT ruggeroridolfi highcancerincidenceinyoungpeopleinitalydogeneticsignaturesrevealtheirenvironmentalcauses |