Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/424072 |
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| _version_ | 1832567657393553408 |
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| author | Giada Santin Luigi Scietti Paola Veneroni Sergio Barni Graziella Bernocchi Maria Grazia Bottone |
| author_facet | Giada Santin Luigi Scietti Paola Veneroni Sergio Barni Graziella Bernocchi Maria Grazia Bottone |
| author_sort | Giada Santin |
| collection | DOAJ |
| description | Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In particular it has been shown that some organelles are cisPt target and are involved in cell death. This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin. The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death. |
| format | Article |
| id | doaj-art-81918fc65c014e67b5a632c130c05250 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-81918fc65c014e67b5a632c130c052502025-02-03T01:00:53ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/424072424072Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular OrganellesGiada Santin0Luigi Scietti1Paola Veneroni2Sergio Barni3Graziella Bernocchi4Maria Grazia Bottone5Istituto di Genetica Molecolare, CNR, 27100 Pavia, ItalyLaboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale, Università di Pavia, Via Ferrata, 27100 Pavia, ItalyLaboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale, Università di Pavia, Via Ferrata, 27100 Pavia, ItalyLaboratorio di Anatomia Comparata e Citologia, Dipartimento di Biologia Animale, Università di Pavia, 27100 Pavia, ItalyLaboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale, Università di Pavia, Via Ferrata, 27100 Pavia, ItalyIstituto di Genetica Molecolare, CNR, 27100 Pavia, ItalyCisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In particular it has been shown that some organelles are cisPt target and are involved in cell death. This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin. The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.http://dx.doi.org/10.1155/2012/424072 |
| spellingShingle | Giada Santin Luigi Scietti Paola Veneroni Sergio Barni Graziella Bernocchi Maria Grazia Bottone Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles International Journal of Cell Biology |
| title | Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles |
| title_full | Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles |
| title_fullStr | Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles |
| title_full_unstemmed | Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles |
| title_short | Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles |
| title_sort | effects of cisplatin in neuroblastoma rat cells damage to cellular organelles |
| url | http://dx.doi.org/10.1155/2012/424072 |
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