The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension
Hyperthyroidism is a clinical state that results from increased thyroid hormone levels which has a significant impact on cardiac function and structure. Graves’ disease is the most common cause of hyperthyroidism in iodine-replete areas. Hyperthyroid heart disease may be associated with pulmonary hy...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/9325289 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564548011294720 |
|---|---|
| author | Xiujuan Zhang Lin Chen Jianping Sheng Chaoying Li Yong He WenXia Han |
| author_facet | Xiujuan Zhang Lin Chen Jianping Sheng Chaoying Li Yong He WenXia Han |
| author_sort | Xiujuan Zhang |
| collection | DOAJ |
| description | Hyperthyroidism is a clinical state that results from increased thyroid hormone levels which has a significant impact on cardiac function and structure. Graves’ disease is the most common cause of hyperthyroidism in iodine-replete areas. Hyperthyroid heart disease may be associated with pulmonary hypertension in patients who have overt hyperthyroidism. To investigate the association of pulmonary hypertension induced by hyperthyroid heart disease and autoantibody, one hundred and one cases with hyperthyroid heart disease who were consecutively admitted to the inpatient department of endocrinology and metabolism of the Shandong Provincial Hospital between November 2014 and April 2018 were collected and analyzed statistically. According to the Independent samples T-test, variance analysis, chi-square test, Pearson linear correlation analysis, and logistic regression, there was a good correlation between pulmonary artery systolic pressure and thyroid stimulating hormone (TSH) and receptor antibodies (TRAb) (r = 0.264, P=0.025) (OR = 1.037, P=0.029), but there was no significant correlation between the pulmonary artery systolic pressure and other thyroid-related parameters (FT3, FT4, TSH, anti-TPO, and anti-TG). Based on variance analysis, PASP rose as the level of TRAb gets higher. What is more, patients with HHD combined with PH showed a significantly higher serum level of TRAb; moreover, serum TRAb concentration was remarkably correlated with the PASP level. Therefore, TRAb participates in the process of pulmonary hypertension caused by hyperthyroid heart disease. |
| format | Article |
| id | doaj-art-818f6c64c5fb42be8337a496d840fc48 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-818f6c64c5fb42be8337a496d840fc482025-02-03T01:10:49ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/93252899325289The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary HypertensionXiujuan Zhang0Lin Chen1Jianping Sheng2Chaoying Li3Yong He4WenXia Han5Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University Cheeloo College of Medicine, Jinan, Shandong, ChinaDepartment of Medicine, The People Hospital of Huaiyin Jinan, Jinan, Shandong, ChinaDepartment of Endocrinology, Zaozhuang Municipal Hospital, Jinan, Shandong, ChinaSchool of Management, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaHyperthyroidism is a clinical state that results from increased thyroid hormone levels which has a significant impact on cardiac function and structure. Graves’ disease is the most common cause of hyperthyroidism in iodine-replete areas. Hyperthyroid heart disease may be associated with pulmonary hypertension in patients who have overt hyperthyroidism. To investigate the association of pulmonary hypertension induced by hyperthyroid heart disease and autoantibody, one hundred and one cases with hyperthyroid heart disease who were consecutively admitted to the inpatient department of endocrinology and metabolism of the Shandong Provincial Hospital between November 2014 and April 2018 were collected and analyzed statistically. According to the Independent samples T-test, variance analysis, chi-square test, Pearson linear correlation analysis, and logistic regression, there was a good correlation between pulmonary artery systolic pressure and thyroid stimulating hormone (TSH) and receptor antibodies (TRAb) (r = 0.264, P=0.025) (OR = 1.037, P=0.029), but there was no significant correlation between the pulmonary artery systolic pressure and other thyroid-related parameters (FT3, FT4, TSH, anti-TPO, and anti-TG). Based on variance analysis, PASP rose as the level of TRAb gets higher. What is more, patients with HHD combined with PH showed a significantly higher serum level of TRAb; moreover, serum TRAb concentration was remarkably correlated with the PASP level. Therefore, TRAb participates in the process of pulmonary hypertension caused by hyperthyroid heart disease.http://dx.doi.org/10.1155/2019/9325289 |
| spellingShingle | Xiujuan Zhang Lin Chen Jianping Sheng Chaoying Li Yong He WenXia Han The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension International Journal of Endocrinology |
| title | The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension |
| title_full | The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension |
| title_fullStr | The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension |
| title_full_unstemmed | The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension |
| title_short | The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension |
| title_sort | association of autoantibodies in hyperthyroid heart disease combined with pulmonary hypertension |
| url | http://dx.doi.org/10.1155/2019/9325289 |
| work_keys_str_mv | AT xiujuanzhang theassociationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT linchen theassociationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT jianpingsheng theassociationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT chaoyingli theassociationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT yonghe theassociationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT wenxiahan theassociationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT xiujuanzhang associationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT linchen associationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT jianpingsheng associationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT chaoyingli associationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT yonghe associationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension AT wenxiahan associationofautoantibodiesinhyperthyroidheartdiseasecombinedwithpulmonaryhypertension |