Microscopic Polyangiitis following Silicone Exposure from Breast Implantation

We describe a case of a patient who developed microscopic polyangiitis (MPA) in the setting of exposure to silicone after breast implantation. A 57-year-old Hispanic woman was admitted to our hospital with complaints of fever, cough, and hemoptysis. She had undergone silicone breast implantation two...

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Main Authors: Judy Tan, Fuad Spath, Rakesh Malhotra, Zaher Hamadeh, Anjali Acharya
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Case Reports in Nephrology
Online Access:http://dx.doi.org/10.1155/2014/902089
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author Judy Tan
Fuad Spath
Rakesh Malhotra
Zaher Hamadeh
Anjali Acharya
author_facet Judy Tan
Fuad Spath
Rakesh Malhotra
Zaher Hamadeh
Anjali Acharya
author_sort Judy Tan
collection DOAJ
description We describe a case of a patient who developed microscopic polyangiitis (MPA) in the setting of exposure to silicone after breast implantation. A 57-year-old Hispanic woman was admitted to our hospital with complaints of fever, cough, and hemoptysis. She had undergone silicone breast implantation two years prior to presentation. She was diagnosed as having microscopic polyangiitis (MPA) based on acute progressive renal failure, hematuria, pulmonary hemorrhage, and positivity for myeloperoxidase-anti-neutrophil cytoplasmic antibody (ANCA). A renal biopsy performed showed focal segmental necrotizing and crescentic glomerulonephritis. The patient received high dose steroids, cyclophosphamide, and plasmapheresis with remarkable clinical response. This case report raises the possibility of the development of MPA after silicone exposure from breast implantation.
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series Case Reports in Nephrology
spelling doaj-art-818de6bbc5a44849b991d5e8e740d4752025-02-03T01:23:32ZengWileyCase Reports in Nephrology2090-66412090-665X2014-01-01201410.1155/2014/902089902089Microscopic Polyangiitis following Silicone Exposure from Breast ImplantationJudy Tan0Fuad Spath1Rakesh Malhotra2Zaher Hamadeh3Anjali Acharya4Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USAWe describe a case of a patient who developed microscopic polyangiitis (MPA) in the setting of exposure to silicone after breast implantation. A 57-year-old Hispanic woman was admitted to our hospital with complaints of fever, cough, and hemoptysis. She had undergone silicone breast implantation two years prior to presentation. She was diagnosed as having microscopic polyangiitis (MPA) based on acute progressive renal failure, hematuria, pulmonary hemorrhage, and positivity for myeloperoxidase-anti-neutrophil cytoplasmic antibody (ANCA). A renal biopsy performed showed focal segmental necrotizing and crescentic glomerulonephritis. The patient received high dose steroids, cyclophosphamide, and plasmapheresis with remarkable clinical response. This case report raises the possibility of the development of MPA after silicone exposure from breast implantation.http://dx.doi.org/10.1155/2014/902089
spellingShingle Judy Tan
Fuad Spath
Rakesh Malhotra
Zaher Hamadeh
Anjali Acharya
Microscopic Polyangiitis following Silicone Exposure from Breast Implantation
Case Reports in Nephrology
title Microscopic Polyangiitis following Silicone Exposure from Breast Implantation
title_full Microscopic Polyangiitis following Silicone Exposure from Breast Implantation
title_fullStr Microscopic Polyangiitis following Silicone Exposure from Breast Implantation
title_full_unstemmed Microscopic Polyangiitis following Silicone Exposure from Breast Implantation
title_short Microscopic Polyangiitis following Silicone Exposure from Breast Implantation
title_sort microscopic polyangiitis following silicone exposure from breast implantation
url http://dx.doi.org/10.1155/2014/902089
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AT fuadspath microscopicpolyangiitisfollowingsiliconeexposurefrombreastimplantation
AT rakeshmalhotra microscopicpolyangiitisfollowingsiliconeexposurefrombreastimplantation
AT zaherhamadeh microscopicpolyangiitisfollowingsiliconeexposurefrombreastimplantation
AT anjaliacharya microscopicpolyangiitisfollowingsiliconeexposurefrombreastimplantation