Relationships of Adrenoceptor Polymorphisms with Obesity
Obesity, hypertension, and type 2 diabetes are rapidly growing public health problems. Heightened sympathetic nerve activity is a well-established observation in obesity, hypertension, and type 2 diabetes. Human obesity, hypertension, and diabetes have strong genetic as well as environmental determi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/609485 |
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| author | Kazuko Masuo Gavin W. Lambert |
| author_facet | Kazuko Masuo Gavin W. Lambert |
| author_sort | Kazuko Masuo |
| collection | DOAJ |
| description | Obesity, hypertension, and type 2 diabetes are rapidly growing public health problems. Heightened sympathetic nerve activity is a well-established observation in obesity, hypertension, and type 2 diabetes. Human obesity, hypertension, and diabetes have strong genetic as well as environmental determinants. Reduced energy expenditure and resting metabolic rate are predictive of weight gain, and the sympathetic nervous system participates in regulating energy balance through thermogenesis. The thermogenic effects of catecholamines in obesity are mainly mediated via the β2, and β3-adrenergic receptors in humans. Further, β2-adrenoceptors importantly influence vascular reactivity and may regulate blood pressure. β-adrenoceptor polymorphisms have also been associated with adrenoceptor desensitization, increased adiposity, insulin resistance, and enhanced sympathetic nervous activity. Many epidemiological studies have shown strong relationships between adrenoceptor polymorphisms and obesity, but the observations have been discordant. This paper will discuss the current topics involving the influence of the sympathetic nervous system and β2- and β3-adrenoceptor polymorphisms in obesity. |
| format | Article |
| id | doaj-art-8185fef6244240809240b354cf64f87b |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-8185fef6244240809240b354cf64f87b2025-02-03T06:08:19ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/609485609485Relationships of Adrenoceptor Polymorphisms with ObesityKazuko Masuo0Gavin W. Lambert1Nucleus Network, Ltd, Baker IDI Heart and Diabetes Research Institute, 89 Commercial Road, Melbourne, VIC 3004, AustraliaHuman Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Research Institute, Melbourne, VIC 3004, AustraliaObesity, hypertension, and type 2 diabetes are rapidly growing public health problems. Heightened sympathetic nerve activity is a well-established observation in obesity, hypertension, and type 2 diabetes. Human obesity, hypertension, and diabetes have strong genetic as well as environmental determinants. Reduced energy expenditure and resting metabolic rate are predictive of weight gain, and the sympathetic nervous system participates in regulating energy balance through thermogenesis. The thermogenic effects of catecholamines in obesity are mainly mediated via the β2, and β3-adrenergic receptors in humans. Further, β2-adrenoceptors importantly influence vascular reactivity and may regulate blood pressure. β-adrenoceptor polymorphisms have also been associated with adrenoceptor desensitization, increased adiposity, insulin resistance, and enhanced sympathetic nervous activity. Many epidemiological studies have shown strong relationships between adrenoceptor polymorphisms and obesity, but the observations have been discordant. This paper will discuss the current topics involving the influence of the sympathetic nervous system and β2- and β3-adrenoceptor polymorphisms in obesity.http://dx.doi.org/10.1155/2011/609485 |
| spellingShingle | Kazuko Masuo Gavin W. Lambert Relationships of Adrenoceptor Polymorphisms with Obesity Journal of Obesity |
| title | Relationships of Adrenoceptor Polymorphisms with Obesity |
| title_full | Relationships of Adrenoceptor Polymorphisms with Obesity |
| title_fullStr | Relationships of Adrenoceptor Polymorphisms with Obesity |
| title_full_unstemmed | Relationships of Adrenoceptor Polymorphisms with Obesity |
| title_short | Relationships of Adrenoceptor Polymorphisms with Obesity |
| title_sort | relationships of adrenoceptor polymorphisms with obesity |
| url | http://dx.doi.org/10.1155/2011/609485 |
| work_keys_str_mv | AT kazukomasuo relationshipsofadrenoceptorpolymorphismswithobesity AT gavinwlambert relationshipsofadrenoceptorpolymorphismswithobesity |