New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination
An 18-year-old male presented with new-onset focal to bilateral tonic-clonic seizures 5 days after receiving the first dose of COVID-19 vaccine. 3 days later, an identical seizure occurred lasting 1 min, leading to an acute presentation to the hospital. In hospital, the patient was loaded with intra...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/8808334 |
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| author | Chun Seng Phua Azman Ali Raymond Shalini Bhaskar |
| author_facet | Chun Seng Phua Azman Ali Raymond Shalini Bhaskar |
| author_sort | Chun Seng Phua |
| collection | DOAJ |
| description | An 18-year-old male presented with new-onset focal to bilateral tonic-clonic seizures 5 days after receiving the first dose of COVID-19 vaccine. 3 days later, an identical seizure occurred lasting 1 min, leading to an acute presentation to the hospital. In hospital, the patient was loaded with intravenous phenytoin and started on levetiracetam with no further seizure recurrence. CT venogram and scalp EEG were unremarkable. MRI brain revealed generalised atrophy with mild bilateral hippocampal atrophy. The patient was maintained on 500 mg levetiracetam twice daily and advised to proceed with subsequent doses of vaccination. Vaccinations have been associated with breakthrough seizures. In this case, COVID-19 vaccination possibly unmasked an underlying predisposition for epilepsy. |
| format | Article |
| id | doaj-art-817f745fe6ec43209d45336698f4b33a |
| institution | Kabale University |
| issn | 2090-6676 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-817f745fe6ec43209d45336698f4b33a2025-02-03T05:29:35ZengWileyCase Reports in Neurological Medicine2090-66762024-01-01202410.1155/2024/8808334New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 VaccinationChun Seng Phua0Azman Ali Raymond1Shalini Bhaskar2Monash UniversityFaculty of MedicineFaculty of MedicineAn 18-year-old male presented with new-onset focal to bilateral tonic-clonic seizures 5 days after receiving the first dose of COVID-19 vaccine. 3 days later, an identical seizure occurred lasting 1 min, leading to an acute presentation to the hospital. In hospital, the patient was loaded with intravenous phenytoin and started on levetiracetam with no further seizure recurrence. CT venogram and scalp EEG were unremarkable. MRI brain revealed generalised atrophy with mild bilateral hippocampal atrophy. The patient was maintained on 500 mg levetiracetam twice daily and advised to proceed with subsequent doses of vaccination. Vaccinations have been associated with breakthrough seizures. In this case, COVID-19 vaccination possibly unmasked an underlying predisposition for epilepsy.http://dx.doi.org/10.1155/2024/8808334 |
| spellingShingle | Chun Seng Phua Azman Ali Raymond Shalini Bhaskar New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination Case Reports in Neurological Medicine |
| title | New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination |
| title_full | New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination |
| title_fullStr | New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination |
| title_full_unstemmed | New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination |
| title_short | New-Onset Focal to Bilateral Tonic-Clonic Seizure Following COVID-19 Vaccination |
| title_sort | new onset focal to bilateral tonic clonic seizure following covid 19 vaccination |
| url | http://dx.doi.org/10.1155/2024/8808334 |
| work_keys_str_mv | AT chunsengphua newonsetfocaltobilateraltonicclonicseizurefollowingcovid19vaccination AT azmanaliraymond newonsetfocaltobilateraltonicclonicseizurefollowingcovid19vaccination AT shalinibhaskar newonsetfocaltobilateraltonicclonicseizurefollowingcovid19vaccination |