Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility. The mechanisms related to their effect differ between humans and other species, thus, d...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/937618 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551055783624704 |
|---|---|
| author | Nikolaos Vrachnis Fotodotis M. Malamas Stavros Sifakis Panayiotis Tsikouras Zoe Iliodromiti |
| author_facet | Nikolaos Vrachnis Fotodotis M. Malamas Stavros Sifakis Panayiotis Tsikouras Zoe Iliodromiti |
| author_sort | Nikolaos Vrachnis |
| collection | DOAJ |
| description | Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility. The mechanisms related to their effect differ between humans and other species, thus, despite extensive research, many questions remain to be answered regarding their mediation in human labor. Immune responses to progesterone and CRH are important for labor. Progesterone acts as an immunomodulator which controls many immune actions during pregnancy, and its withdrawal releases the inhibitory action on inflammatory pathways. In humans, a “functional” progesterone withdrawal occurs with onset of labor through changes in progesterone metabolism, progesterone receptors, and other molecules that either facilitate or antagonize progesterone function. Placental CRH acts on the fetal pituitary-adrenal axis to stimulate adrenal production of androgens and cortisol and also acts directly on myometrial cells via its receptors. CRH also affects inflammatory signals and vice versa. Interactions between progesterone and CRH additionally occur during labor. We describe the role of these two hormones in human myometrium and their interactions with the immune system during labor. |
| format | Article |
| id | doaj-art-817c22fd121b4042bdcbca544a86a58b |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-817c22fd121b4042bdcbca544a86a58b2025-02-03T06:05:11ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/937618937618Immune Aspects and Myometrial Actions of Progesterone and CRH in LaborNikolaos Vrachnis0Fotodotis M. Malamas1Stavros Sifakis2Panayiotis Tsikouras3Zoe Iliodromiti42nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, University of Athens Medical School, Alexandra Hospital, 11528 Athens, GreeceDepartment of Obstetrics and Gynecology, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceDepartment of Obstetrics and Gynecology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupoli, Greece2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, 11528 Athens, GreeceProgesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility. The mechanisms related to their effect differ between humans and other species, thus, despite extensive research, many questions remain to be answered regarding their mediation in human labor. Immune responses to progesterone and CRH are important for labor. Progesterone acts as an immunomodulator which controls many immune actions during pregnancy, and its withdrawal releases the inhibitory action on inflammatory pathways. In humans, a “functional” progesterone withdrawal occurs with onset of labor through changes in progesterone metabolism, progesterone receptors, and other molecules that either facilitate or antagonize progesterone function. Placental CRH acts on the fetal pituitary-adrenal axis to stimulate adrenal production of androgens and cortisol and also acts directly on myometrial cells via its receptors. CRH also affects inflammatory signals and vice versa. Interactions between progesterone and CRH additionally occur during labor. We describe the role of these two hormones in human myometrium and their interactions with the immune system during labor.http://dx.doi.org/10.1155/2012/937618 |
| spellingShingle | Nikolaos Vrachnis Fotodotis M. Malamas Stavros Sifakis Panayiotis Tsikouras Zoe Iliodromiti Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor Clinical and Developmental Immunology |
| title | Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor |
| title_full | Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor |
| title_fullStr | Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor |
| title_full_unstemmed | Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor |
| title_short | Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor |
| title_sort | immune aspects and myometrial actions of progesterone and crh in labor |
| url | http://dx.doi.org/10.1155/2012/937618 |
| work_keys_str_mv | AT nikolaosvrachnis immuneaspectsandmyometrialactionsofprogesteroneandcrhinlabor AT fotodotismmalamas immuneaspectsandmyometrialactionsofprogesteroneandcrhinlabor AT stavrossifakis immuneaspectsandmyometrialactionsofprogesteroneandcrhinlabor AT panayiotistsikouras immuneaspectsandmyometrialactionsofprogesteroneandcrhinlabor AT zoeiliodromiti immuneaspectsandmyometrialactionsofprogesteroneandcrhinlabor |