Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants
Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/6386453 |
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| author | Abolfazl Khoshdel Soleiman Kheiri Peyman Omidvari Fahimeh Moradi Majid Hamidi Hossein Teimori |
| author_facet | Abolfazl Khoshdel Soleiman Kheiri Peyman Omidvari Fahimeh Moradi Majid Hamidi Hossein Teimori |
| author_sort | Abolfazl Khoshdel |
| collection | DOAJ |
| description | Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17–45 (mean: 28.6±5.3) years and 24–34 (mean: 34.3±2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P<0.05). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082. |
| format | Article |
| id | doaj-art-817a48b99f7b44eda02cc504b8638a3d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-817a48b99f7b44eda02cc504b8638a3d2025-02-03T01:26:20ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/63864536386453Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm InfantsAbolfazl Khoshdel0Soleiman Kheiri1Peyman Omidvari2Fahimeh Moradi3Majid Hamidi4Hossein Teimori5Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranClinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, IranCellular and Molecular Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranSubspecialty of Pediatrics, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Medical Genetics, Shahrekord University of Medical Sciences, Shahrekord, IranCytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17–45 (mean: 28.6±5.3) years and 24–34 (mean: 34.3±2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P<0.05). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082.http://dx.doi.org/10.1155/2017/6386453 |
| spellingShingle | Abolfazl Khoshdel Soleiman Kheiri Peyman Omidvari Fahimeh Moradi Majid Hamidi Hossein Teimori Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants Mediators of Inflammation |
| title | Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants |
| title_full | Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants |
| title_fullStr | Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants |
| title_full_unstemmed | Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants |
| title_short | Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants |
| title_sort | association between interleukin 10 1082 g a and tumor necrosis factor α 308 g a gene polymorphisms and respiratory distress syndrome in iranian preterm infants |
| url | http://dx.doi.org/10.1155/2017/6386453 |
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