Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity
A series of some new 2,5-disubstituted-1,3,4-oxadiazoles 4(a–i) have been conveniently synthesized by intramolecular oxidative cyclization of (E)-2-(arylbenzylidene)-2-[(4-methoxyphenyl)amino]acetohydrazides promoted by iodobenzene diacetate as an oxidant. The structures of the synthesized compounds...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/121029 |
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| author | B. N. Prasanna Kumar K. N. Mohana L. Mallesha |
| author_facet | B. N. Prasanna Kumar K. N. Mohana L. Mallesha |
| author_sort | B. N. Prasanna Kumar |
| collection | DOAJ |
| description | A series of some new 2,5-disubstituted-1,3,4-oxadiazoles 4(a–i) have been conveniently synthesized by intramolecular oxidative cyclization of (E)-2-(arylbenzylidene)-2-[(4-methoxyphenyl)amino]acetohydrazides promoted by iodobenzene diacetate as an oxidant. The structures of the synthesized compounds have been confirmed by 1H and 13C NMR, IR, MS, and elemental analysis. All the newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method. Compounds 4g, 4d, and 4a were found to be the most potent of this series. The same compounds showed no neurotoxicity at the maximum dose administered. |
| format | Article |
| id | doaj-art-8173a8494dc54327a453096a4833ca8c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-8173a8494dc54327a453096a4833ca8c2025-02-03T01:03:09ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/121029121029Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant ActivityB. N. Prasanna Kumar0K. N. Mohana1L. Mallesha2Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, IndiaDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, IndiaPG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 25, IndiaA series of some new 2,5-disubstituted-1,3,4-oxadiazoles 4(a–i) have been conveniently synthesized by intramolecular oxidative cyclization of (E)-2-(arylbenzylidene)-2-[(4-methoxyphenyl)amino]acetohydrazides promoted by iodobenzene diacetate as an oxidant. The structures of the synthesized compounds have been confirmed by 1H and 13C NMR, IR, MS, and elemental analysis. All the newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method. Compounds 4g, 4d, and 4a were found to be the most potent of this series. The same compounds showed no neurotoxicity at the maximum dose administered.http://dx.doi.org/10.1155/2013/121029 |
| spellingShingle | B. N. Prasanna Kumar K. N. Mohana L. Mallesha Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity Journal of Chemistry |
| title | Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity |
| title_full | Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity |
| title_fullStr | Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity |
| title_full_unstemmed | Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity |
| title_short | Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity |
| title_sort | synthesis of n 5 aryl 1 3 4 oxadiazole 2 yl methyl 4 methoxyaniline derivatives and their anticonvulsant activity |
| url | http://dx.doi.org/10.1155/2013/121029 |
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