C-reactive protein as a diagnostic marker for ovarian carcinoma
Ovarian carcinoma is a leading cause of death in gynecological cancers, making early detection crucial for improving survival rates. C-reactive protein (CRP) has shown promise as a cost-effective biomarker to distinguish ovarian carcinoma from benign ovarian masses. Elevated CRP levels are associat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-01-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/ijm/article/view/1819 |
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| _version_ | 1832592869387403264 |
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| author | Angga Dewi Umar Wahyu Syahrul Rauf Susiawaty Susiawaty Maisuri T. Chalid Nugraha Utama Pelupessy Irma Savitri |
| author_facet | Angga Dewi Umar Wahyu Syahrul Rauf Susiawaty Susiawaty Maisuri T. Chalid Nugraha Utama Pelupessy Irma Savitri |
| author_sort | Angga Dewi Umar Wahyu |
| collection | DOAJ |
| description |
Ovarian carcinoma is a leading cause of death in gynecological cancers, making early detection crucial for improving survival rates. C-reactive protein (CRP) has shown promise as a cost-effective biomarker to distinguish ovarian carcinoma from benign ovarian masses. Elevated CRP levels are associated with an increased risk of ovarian cancer. This cross-sectional study included 87 patients: 59 with ovarian carcinoma and 28 with ovarian cysts. The aim was to evaluate CRP as a diagnostic marker to improve early detection and clinical management of ovarian carcinoma. CRP levels were measured using the enzyme-linked immunosorbent assay method. Statistical analysis was conducted to assess the differences in CRP levels between the ovarian carcinoma group and the ovarian cyst group. All statistical analyses were performed using the Statistical Program for Social Sciences (IBM SPSS 24, IL, USA). Most subjects in the study were 50 years old or younger (69%) and had ovarian carcinoma (67.8%). Age over 50 [odds ratio (OR) 5.71, p=0.01] and menopausal status (OR 4.72, p=0.01) were significant risk factors for ovarian carcinoma. No significant difference in CRP levels was found between ovarian carcinoma and ovarian cyst patients (p=0.23). Based on the results, CRP cannot be used as an effective predictor to differentiate ovarian carcinoma from ovarian cysts.
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| format | Article |
| id | doaj-art-8162ed8ed52f4fa6b06aa6a216bb3aa6 |
| institution | Kabale University |
| issn | 1877-9344 1877-9352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj-art-8162ed8ed52f4fa6b06aa6a216bb3aa62025-01-21T02:35:44ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522025-01-0119110.4081/itjm.2025.1819C-reactive protein as a diagnostic marker for ovarian carcinomaAngga Dewi Umar Wahyu0Syahrul Rauf1Susiawaty Susiawaty2Maisuri T. Chalid3Nugraha Utama Pelupessy4Irma Savitri5Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar Ovarian carcinoma is a leading cause of death in gynecological cancers, making early detection crucial for improving survival rates. C-reactive protein (CRP) has shown promise as a cost-effective biomarker to distinguish ovarian carcinoma from benign ovarian masses. Elevated CRP levels are associated with an increased risk of ovarian cancer. This cross-sectional study included 87 patients: 59 with ovarian carcinoma and 28 with ovarian cysts. The aim was to evaluate CRP as a diagnostic marker to improve early detection and clinical management of ovarian carcinoma. CRP levels were measured using the enzyme-linked immunosorbent assay method. Statistical analysis was conducted to assess the differences in CRP levels between the ovarian carcinoma group and the ovarian cyst group. All statistical analyses were performed using the Statistical Program for Social Sciences (IBM SPSS 24, IL, USA). Most subjects in the study were 50 years old or younger (69%) and had ovarian carcinoma (67.8%). Age over 50 [odds ratio (OR) 5.71, p=0.01] and menopausal status (OR 4.72, p=0.01) were significant risk factors for ovarian carcinoma. No significant difference in CRP levels was found between ovarian carcinoma and ovarian cyst patients (p=0.23). Based on the results, CRP cannot be used as an effective predictor to differentiate ovarian carcinoma from ovarian cysts. https://www.italjmed.org/ijm/article/view/1819C-reactive proteinovarian carcinomaovarian cyst |
| spellingShingle | Angga Dewi Umar Wahyu Syahrul Rauf Susiawaty Susiawaty Maisuri T. Chalid Nugraha Utama Pelupessy Irma Savitri C-reactive protein as a diagnostic marker for ovarian carcinoma Italian Journal of Medicine C-reactive protein ovarian carcinoma ovarian cyst |
| title | C-reactive protein as a diagnostic marker for ovarian carcinoma |
| title_full | C-reactive protein as a diagnostic marker for ovarian carcinoma |
| title_fullStr | C-reactive protein as a diagnostic marker for ovarian carcinoma |
| title_full_unstemmed | C-reactive protein as a diagnostic marker for ovarian carcinoma |
| title_short | C-reactive protein as a diagnostic marker for ovarian carcinoma |
| title_sort | c reactive protein as a diagnostic marker for ovarian carcinoma |
| topic | C-reactive protein ovarian carcinoma ovarian cyst |
| url | https://www.italjmed.org/ijm/article/view/1819 |
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