C-28 linker length modulates the activity of second-generation HIV-1 maturation inhibitors

C-28 linker length modulates the activity of second-generation HIV-1 maturation inhibitors

Abstract Maturation inhibitors (MIs) block HIV-1 maturation by preventing the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a first-in-class MI, displayed sub-optimal efficacy in clinical trials due to presence of SP1:V7A polymorphism in the Gag protein.This polymorp...

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Bibliographic Details
Main Authors: K. C. Yuvraj, Aradhana Singh, Sayantani Datta, Ritika Das, Pranjal Raj Saxena, Subash Chapagain, T. J. Nitz, Carl Wild, Ritu Gaur
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Virology Journal
Subjects:
Maturation inhibitors
C-28 Linker length
HIV-1 Subtype B and C
HIV-1 maturation
Online Access:https://doi.org/10.1186/s12985-025-02635-8
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