A Toolbox for Predicting G-Quadruplex Formation and Stability
G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Und...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/564946 |
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| _version_ | 1832549864916910080 |
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| author | Han Min Wong Oliver Stegle Simon Rodgers Julian Leon Huppert |
| author_facet | Han Min Wong Oliver Stegle Simon Rodgers Julian Leon Huppert |
| author_sort | Han Min Wong |
| collection | DOAJ |
| description | G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis. |
| format | Article |
| id | doaj-art-8145d2a6b65e4c7daeaccbf67cc741cd |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-8145d2a6b65e4c7daeaccbf67cc741cd2025-02-03T06:08:17ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/564946564946A Toolbox for Predicting G-Quadruplex Formation and StabilityHan Min Wong0Oliver Stegle1Simon Rodgers2Julian Leon Huppert3Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UKMax-Planck-Institutes Tübingen, Spemanstraßse 38, 72076 Tübingen, GermanyThaze Ltd, 121 Mowbray Road, Cambridge CB1 7SP, UKCavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UKG-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.http://dx.doi.org/10.4061/2010/564946 |
| spellingShingle | Han Min Wong Oliver Stegle Simon Rodgers Julian Leon Huppert A Toolbox for Predicting G-Quadruplex Formation and Stability Journal of Nucleic Acids |
| title | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_full | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_fullStr | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_full_unstemmed | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_short | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_sort | toolbox for predicting g quadruplex formation and stability |
| url | http://dx.doi.org/10.4061/2010/564946 |
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