Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease
Aim. Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease (CHD).Material and methods. The study included 78 men aged 28-50 years: 49 CHD patients with angiography-verified coronary artery atherosclerosis and 29 cont...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2009-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1848 |
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| author | T. V. Balakhonova S. G. Kozlov Kh. A. Makhmudova M. I. Tripoten A. A. Lyakishev V. V. Kukharchuk |
| author_facet | T. V. Balakhonova S. G. Kozlov Kh. A. Makhmudova M. I. Tripoten A. A. Lyakishev V. V. Kukharchuk |
| author_sort | T. V. Balakhonova |
| collection | DOAJ |
| description | Aim. Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease (CHD).Material and methods. The study included 78 men aged 28-50 years: 49 CHD patients with angiography-verified coronary artery atherosclerosis and 29 controls (control group, CG), without clinical atherosclerosis manifestations. All participants underwent a standard carotid artery (CA) ultrasound. Brachial artery flow-dependent vasodilatation (FDVD) was assessed in reactive hyperemia test.Results. Among CHD patients, intima-media thickness (IMT) for common CA (0,88±0,23 mm) was significantly higher than in CG individuals (0,76±0,18 mm; р=0,01). Atherosclerotic plaques in common CA were observed in 91,8% of the CHD patients and 27,6% of controls (р<0,001). Multiple plaques were observed in 80% and 14%, respectively (р<0,001). Average brachial artery FDVD (5,8±2,2%) was significantly higher than that in CHD patients (4,5±2,8%; р=0,03).Conclusion. No significant differences in the prevalence of normal FDVD were observed between two groups. Increased IMT and multiple atherosclerotic plaques in common CA were associated with higher CHD risk in young and middle-aged men. |
| format | Article |
| id | doaj-art-813113b95a0b47d5a67ec72eea3fe098 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2009-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-813113b95a0b47d5a67ec72eea3fe0982025-08-20T03:43:27Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252009-10-018511151563Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart diseaseT. V. Balakhonova0S. G. Kozlov1Kh. A. Makhmudova2M. I. Tripoten3A. A. Lyakishev4V. V. Kukharchuk5L.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexL.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexL.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexL.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexL.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexL.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical ComplexAim. Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease (CHD).Material and methods. The study included 78 men aged 28-50 years: 49 CHD patients with angiography-verified coronary artery atherosclerosis and 29 controls (control group, CG), without clinical atherosclerosis manifestations. All participants underwent a standard carotid artery (CA) ultrasound. Brachial artery flow-dependent vasodilatation (FDVD) was assessed in reactive hyperemia test.Results. Among CHD patients, intima-media thickness (IMT) for common CA (0,88±0,23 mm) was significantly higher than in CG individuals (0,76±0,18 mm; р=0,01). Atherosclerotic plaques in common CA were observed in 91,8% of the CHD patients and 27,6% of controls (р<0,001). Multiple plaques were observed in 80% and 14%, respectively (р<0,001). Average brachial artery FDVD (5,8±2,2%) was significantly higher than that in CHD patients (4,5±2,8%; р=0,03).Conclusion. No significant differences in the prevalence of normal FDVD were observed between two groups. Increased IMT and multiple atherosclerotic plaques in common CA were associated with higher CHD risk in young and middle-aged men.https://cardiovascular.elpub.ru/jour/article/view/1848coronary heart diseaseflow-dependent vasodilatationintima-media thicknesscarotid arteriesyoung age |
| spellingShingle | T. V. Balakhonova S. G. Kozlov Kh. A. Makhmudova M. I. Tripoten A. A. Lyakishev V. V. Kukharchuk Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease Кардиоваскулярная терапия и профилактика coronary heart disease flow-dependent vasodilatation intima-media thickness carotid arteries young age |
| title | Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease |
| title_full | Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease |
| title_fullStr | Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease |
| title_full_unstemmed | Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease |
| title_short | Ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle-aged men with coronary heart disease |
| title_sort | ultrasound assessment of carotid artery atherosclerosis and endothelial function in young and middle aged men with coronary heart disease |
| topic | coronary heart disease flow-dependent vasodilatation intima-media thickness carotid arteries young age |
| url | https://cardiovascular.elpub.ru/jour/article/view/1848 |
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