A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease
Bone loss is characteristic of the ageing process and a common complication of many autoimmune diseases. Research has highlighted a potential role of autoantibodies in pathologic bone loss. The confounding effects of immunomodulatory drugs make it difficult to establish the contribution of autoantib...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/9407971 |
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| author | Rosebella A. Iseme Mark McEvoy Brian Kelly Linda Agnew Frederick R. Walker Michael Boyle John Attia |
| author_facet | Rosebella A. Iseme Mark McEvoy Brian Kelly Linda Agnew Frederick R. Walker Michael Boyle John Attia |
| author_sort | Rosebella A. Iseme |
| collection | DOAJ |
| description | Bone loss is characteristic of the ageing process and a common complication of many autoimmune diseases. Research has highlighted a potential role of autoantibodies in pathologic bone loss. The confounding effects of immunomodulatory drugs make it difficult to establish the contribution of autoantibodies amongst autoimmune disease sufferers. We attempted to examine the relationship between autoantibodies and bone mass in a population of 2812 elderly participants without clinical autoimmune disease. Serum samples were assayed for a panel of autoantibodies (anti-nuclear, extractable nuclear antigen, anti-neutrophil cytoplasmic, thyroid peroxidase, tissue transglutaminase, anti-cardiolipin, rheumatoid factor, and cyclic citrullinated peptide). Bone mass was measured using quantitative ultrasound (QUS) of the calcaneus. The relationship between each autoantibody and bone mass was determined using linear regression models. Anti-nuclear autoantibodies were the most prevalent, positive in approximately 11%, and borderline in roughly 23% of our sample. They were also the only autoantibody observed to be significantly associated with QUS index in the univariate analysis (n=1628; r=−0.20; 95% CI: −0.40–0.00; p=0.046). However, statistical significance was lost after adjustment for various other potential confounders. None of the other autoantibodies was associated with QUS index in either univariate or multivariate analysis. We are limited by the cross-sectional nature of the study and the low prevalence of autoantibodies in our nonclinical sample. |
| format | Article |
| id | doaj-art-8110812cd838485d9c6f060f5b9c5222 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-8110812cd838485d9c6f060f5b9c52222025-02-03T05:53:40ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/94079719407971A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune DiseaseRosebella A. Iseme0Mark McEvoy1Brian Kelly2Linda Agnew3Frederick R. Walker4Michael Boyle5John Attia6Department of Population and Reproductive Health, School of Public Health, Kenyatta University, P.O. Box 43844, Nairobi 00100, KenyaSchool of Medicine & Public Health, The University of Newcastle, Callaghan, NSW 2308, AustraliaSchool of Medicine & Public Health, The University of Newcastle, Callaghan, NSW 2308, AustraliaBrain Behaviour Research Group, School of Science and Technology, University of New England, Armidale, NSW 2351, AustraliaSchool of Medicine & Public Health, The University of Newcastle, Callaghan, NSW 2308, AustraliaSchool of Medicine & Public Health, The University of Newcastle, Callaghan, NSW 2308, AustraliaSchool of Medicine & Public Health, The University of Newcastle, Callaghan, NSW 2308, AustraliaBone loss is characteristic of the ageing process and a common complication of many autoimmune diseases. Research has highlighted a potential role of autoantibodies in pathologic bone loss. The confounding effects of immunomodulatory drugs make it difficult to establish the contribution of autoantibodies amongst autoimmune disease sufferers. We attempted to examine the relationship between autoantibodies and bone mass in a population of 2812 elderly participants without clinical autoimmune disease. Serum samples were assayed for a panel of autoantibodies (anti-nuclear, extractable nuclear antigen, anti-neutrophil cytoplasmic, thyroid peroxidase, tissue transglutaminase, anti-cardiolipin, rheumatoid factor, and cyclic citrullinated peptide). Bone mass was measured using quantitative ultrasound (QUS) of the calcaneus. The relationship between each autoantibody and bone mass was determined using linear regression models. Anti-nuclear autoantibodies were the most prevalent, positive in approximately 11%, and borderline in roughly 23% of our sample. They were also the only autoantibody observed to be significantly associated with QUS index in the univariate analysis (n=1628; r=−0.20; 95% CI: −0.40–0.00; p=0.046). However, statistical significance was lost after adjustment for various other potential confounders. None of the other autoantibodies was associated with QUS index in either univariate or multivariate analysis. We are limited by the cross-sectional nature of the study and the low prevalence of autoantibodies in our nonclinical sample.http://dx.doi.org/10.1155/2018/9407971 |
| spellingShingle | Rosebella A. Iseme Mark McEvoy Brian Kelly Linda Agnew Frederick R. Walker Michael Boyle John Attia A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease Journal of Immunology Research |
| title | A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease |
| title_full | A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease |
| title_fullStr | A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease |
| title_full_unstemmed | A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease |
| title_short | A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease |
| title_sort | cross sectional study of the association between autoantibodies and qualitative ultrasound index of bone in an elderly sample without clinical autoimmune disease |
| url | http://dx.doi.org/10.1155/2018/9407971 |
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