P483: Novel biallelic LIG3 mutations causing lethal phenotype of mtDNA depletion syndrome 20: A case solved by multi-omics research re-analysis - Erica Schindewolf; Gonench Kilich; Kathleen Sullivan; Rebecca Ganetzky; Kelly Hassey; Kelly Mauer; Christopher Breen; Tanaya Jadhav; Adeline Vanderver; Cara Skraban; Ramakrishnan Rajagopalan (Genetics in Medicine Open)