The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study
ABSTRACT BACKGROUND: Insulin resistance often occurs in patients with chronic kidney disease (CKD) owing to mineral and bone metabolism disorders. Fibroblast growth factor (FGF)-23 and soluble klotho (s-KL) play crucial roles in linking CKD with mineral and bone metabolism. OBJECTIVE: This study a...
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Associação Paulista de Medicina
2025-01-01
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| Series: | São Paulo Medical Journal |
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| author | Beyza Algul Durak Melahat Coban |
| author_facet | Beyza Algul Durak Melahat Coban |
| author_sort | Beyza Algul Durak |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Insulin resistance often occurs in patients with chronic kidney disease (CKD) owing to mineral and bone metabolism disorders. Fibroblast growth factor (FGF)-23 and soluble klotho (s-KL) play crucial roles in linking CKD with mineral and bone metabolism. OBJECTIVE: This study aimed to examine the relationship between insulin resistance and FGF-23 and s-KL in patients with non-diabetic pre-dialysis patients with CKD. DESIGN AND SETTING: This research was conducted in the Ankara Bilkent City Hospital Nephrology Clinic. Ankara,Turkey. METHODS: This study included 133 male and 150 female patients with pre-dialysis CKD. The patients were compared with 80 healthy individuals. FGF-23 and s-KL levels were determined using enzyme-linked immunosorbent assay kits. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to determine insulin resistance. RESULTS: Creatinine, urine protein/creatinine ratio (UPCR), log10 FGF-23, log 10 s-KL, and HOMA-IR were notably higher, while glomerular filtration rate was notably lower, in patients than in healthy individuals. Stage 5 CKD, log10 FGF-23, creatinine, and UPCR were significantly higher in patients with HOMA-IR > 3.06 compared to those with HOMA-IR ≤ 3.06. No difference was observed in s-KL levels between the two groups. Univariate and multivariate logistic regression analyses revealed an increase in HOMA-IR and log10 FGF-23 values. CONCLUSIONS: Insulin resistance, serum FGF-23, and s-KL levels increased in patients compared with healthy individuals. Higher creatinine, proteinuria, and FGF-23 levels were associated with greater insulin resistance. The study highlighted a significant relationship between insulin resistance and FGF-23. |
| format | Article |
| id | doaj-art-810dbc1881fa42aa9dd2ee0a6175bfc8 |
| institution | Kabale University |
| issn | 1806-9460 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj-art-810dbc1881fa42aa9dd2ee0a6175bfc82025-02-04T07:38:44ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602025-01-01143110.1590/1516-3180.2024.0103.03072024The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional studyBeyza Algul Durakhttps://orcid.org/0000-0002-3182-4382Melahat Cobanhttps://orcid.org/0000-0001-5761-7675ABSTRACT BACKGROUND: Insulin resistance often occurs in patients with chronic kidney disease (CKD) owing to mineral and bone metabolism disorders. Fibroblast growth factor (FGF)-23 and soluble klotho (s-KL) play crucial roles in linking CKD with mineral and bone metabolism. OBJECTIVE: This study aimed to examine the relationship between insulin resistance and FGF-23 and s-KL in patients with non-diabetic pre-dialysis patients with CKD. DESIGN AND SETTING: This research was conducted in the Ankara Bilkent City Hospital Nephrology Clinic. Ankara,Turkey. METHODS: This study included 133 male and 150 female patients with pre-dialysis CKD. The patients were compared with 80 healthy individuals. FGF-23 and s-KL levels were determined using enzyme-linked immunosorbent assay kits. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to determine insulin resistance. RESULTS: Creatinine, urine protein/creatinine ratio (UPCR), log10 FGF-23, log 10 s-KL, and HOMA-IR were notably higher, while glomerular filtration rate was notably lower, in patients than in healthy individuals. Stage 5 CKD, log10 FGF-23, creatinine, and UPCR were significantly higher in patients with HOMA-IR > 3.06 compared to those with HOMA-IR ≤ 3.06. No difference was observed in s-KL levels between the two groups. Univariate and multivariate logistic regression analyses revealed an increase in HOMA-IR and log10 FGF-23 values. CONCLUSIONS: Insulin resistance, serum FGF-23, and s-KL levels increased in patients compared with healthy individuals. Higher creatinine, proteinuria, and FGF-23 levels were associated with greater insulin resistance. The study highlighted a significant relationship between insulin resistance and FGF-23.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802025000100211&lng=en&tlng=enFibroblast growth factor 23CreatinineGlomerular filtration ratePre-dialysis chronic kidney diseaseSoluble klothoHomeostasis model assessment of insulin resistance |
| spellingShingle | Beyza Algul Durak Melahat Coban The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study São Paulo Medical Journal Fibroblast growth factor 23 Creatinine Glomerular filtration rate Pre-dialysis chronic kidney disease Soluble klotho Homeostasis model assessment of insulin resistance |
| title | The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study |
| title_full | The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study |
| title_fullStr | The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study |
| title_full_unstemmed | The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study |
| title_short | The relationship between insulin resistance and fibroblast growth factor 23 in patients with non-diabetic pre-dialysis chronic kidney disease: a cross-sectional study |
| title_sort | relationship between insulin resistance and fibroblast growth factor 23 in patients with non diabetic pre dialysis chronic kidney disease a cross sectional study |
| topic | Fibroblast growth factor 23 Creatinine Glomerular filtration rate Pre-dialysis chronic kidney disease Soluble klotho Homeostasis model assessment of insulin resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802025000100211&lng=en&tlng=en |
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