Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization

Abstract Lack in understanding of the mechanism on brachial plexus avulsion (BPA)-induced neuropathic pain (NP) is the key factor restricting its treatment. In the current investigation, we focused on the nociceptor-localized K+-Cl− cotransporter 2 (KCC2) to investigate its role in BPA-induced NP an...

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Bibliographic Details
Main Authors: Hang Xian, Huan Guo, Yuan-Ying Liu, Sui-Bin Ma, Rui Zhao, Jian-Lei Zhang, Hang Zhang, Rou-Gang Xie, Xu-Cheng Guo, Jie Ren, Sheng-Xi Wu, Ceng Luo, Rui Cong
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell & Bioscience
Subjects:
Brachial plexus avulsion
Neuropathic pain
Central sensitization
Peripheral sensitization
KCC2
BDNF
Online Access:https://doi.org/10.1186/s13578-025-01354-5
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