PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation

PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation

The low expression of period circadian regulator 3 (PER3) in head and neck squamous cell carcinoma is closely correlated with tumor size and invasion depth. Hypoxia-inducible factor 1 subunit alpha (HIF-1α) regulates epithelial-mesenchymal transition (EMT) transcription factors, activates EMT, and p...

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Bibliographic Details
Main Authors: Yaoxu Li, Bing Li, Kai Yang, Lihua Zhu, Hong Tang, Yinpei Huang, Jinhai Deng, Jun Duan
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Translational Oncology
Subjects:
Oral squamous cell carcinoma
Metastasis
Hypoxia-inducible factor 1 subunit alpha
Period circadian regulator 3
Promoter methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332400384X
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