Therapeutic effect of selective interleukin-2-inducible tyrosine kinase inhibitor in orbital fibroblasts from patients with Graves’ orbitopathy

Therapeutic effect of selective interleukin-2-inducible tyrosine kinase inhibitor in orbital fibroblasts from patients with Graves’ orbitopathy

Interleukin-2-inducible tyrosine kinase (ITK) is a crucial cytoplasmic protein in the T-cell signaling pathway. Here, we aimed to demonstrate the anti-inflammatory effect of the selective IL-2-induced tyrosine kinase inhibitor BMS-509744 (BMS) on Graves’ orbitopathy (GO) in an in vitro model. ITK mR...

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Bibliographic Details
Main Authors: Yeonjung Yoon, Hyun Young Park, Min Kyung Chae, Sun Young Jang, Jin Sook Yoon
Format: Article
Language:English
Published: The Japan Endocrine Society 2024-09-01
Series:Endocrine Journal
Subjects:
graves’ orbitopathy
inflammation
interleukin-2 inducible tyrosine kinase
orbital fibroblast
thyroid eye disease
Online Access:https://www.jstage.jst.go.jp/article/endocrj/71/9/71_EJ23-0729/_html/-char/en
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