Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus)
This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Rese...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/2047803 |
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| author | Rosângela C. Rodrigues Flávia Schechtman Belham Ana Garcia Corina Satler Carlos Tomaz Maria Clotilde H. Tavares |
| author_facet | Rosângela C. Rodrigues Flávia Schechtman Belham Ana Garcia Corina Satler Carlos Tomaz Maria Clotilde H. Tavares |
| author_sort | Rosângela C. Rodrigues |
| collection | DOAJ |
| description | This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. The physiological parameters were accessed by means of 13 blood samples from each female, whereas three were gathered during the baseline and 10 samples were collected during the treatment phase. The results showed that the contraceptive use provoked changes in hematological coagulation factors such as an increase in the amount of platelets (p=0.039) and a reduction in both prothrombin (p<0.001) and thromboplastin coagulation time (p<0.001). These results are similar to what has been observed in human patients; thus, it is concluded that S. libidinosus can be successfully used in studies about the physiological impact of hormonal contraceptives. |
| format | Article |
| id | doaj-art-80f29fd5249d4685a6855be6bfd5abd0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-80f29fd5249d4685a6855be6bfd5abd02025-02-03T05:52:40ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/20478032047803Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus)Rosângela C. Rodrigues0Flávia Schechtman Belham1Ana Garcia2Corina Satler3Carlos Tomaz4Maria Clotilde H. Tavares5Department of Biological Sciences, State University of Feira de Santana, Avenida Transnordestina, s/n - Novo Horizonte CEP, 44036-900 Feira de Santana, Bahia, BrazilLaboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, BrazilLaboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, BrazilFaculty of Ceilandia, University of Brasilia, Brasilia, BrazilNeuroscience Research Program, CEUMA University, São Luís, BrazilLaboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, BrazilThis study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. The physiological parameters were accessed by means of 13 blood samples from each female, whereas three were gathered during the baseline and 10 samples were collected during the treatment phase. The results showed that the contraceptive use provoked changes in hematological coagulation factors such as an increase in the amount of platelets (p=0.039) and a reduction in both prothrombin (p<0.001) and thromboplastin coagulation time (p<0.001). These results are similar to what has been observed in human patients; thus, it is concluded that S. libidinosus can be successfully used in studies about the physiological impact of hormonal contraceptives.http://dx.doi.org/10.1155/2019/2047803 |
| spellingShingle | Rosângela C. Rodrigues Flávia Schechtman Belham Ana Garcia Corina Satler Carlos Tomaz Maria Clotilde H. Tavares Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus) International Journal of Endocrinology |
| title | Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus) |
| title_full | Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus) |
| title_fullStr | Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus) |
| title_full_unstemmed | Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus) |
| title_short | Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys (Sapajus libidinosus) |
| title_sort | continuous use of combined hormonal contraceptive and the effect on blood coagulation factors in female capuchin monkeys sapajus libidinosus |
| url | http://dx.doi.org/10.1155/2019/2047803 |
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