Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure
Abstract Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LV...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-06-01
|
| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.12657 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544414339170304 |
|---|---|
| author | Marcelo Rodrigues Dos Santos Guilherme Wesley Peixoto daFonseca Letícia Pironato Sherveninas Francis Ribeiro deSouza Antônio Carlos Battaglia Filho Caio Eduardo Novaes Rosa Maria Rodrigues Pereira Carlos Eduardo Negrão Antônio Carlos Pereira Barretto Maria‐Janieire de Nazaré Nunes Alves |
| author_facet | Marcelo Rodrigues Dos Santos Guilherme Wesley Peixoto daFonseca Letícia Pironato Sherveninas Francis Ribeiro deSouza Antônio Carlos Battaglia Filho Caio Eduardo Novaes Rosa Maria Rodrigues Pereira Carlos Eduardo Negrão Antônio Carlos Pereira Barretto Maria‐Janieire de Nazaré Nunes Alves |
| author_sort | Marcelo Rodrigues Dos Santos |
| collection | DOAJ |
| description | Abstract Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) <40%. Body composition (by using dual x‐ray absorptiometry) and peak VO2 (by cardiopulmonary exercise testing) were measured. Sarcopenic obesity was defined according to the Foundation for the National Institutes of Health criteria (FNIH). Blood sample for metabolic and hormonal parameters were measured. Fifteen patients (12.7%) showed sarcopenic obesity (body mass index > 25 kg/m2 with FNIH index < 0.789). The median A/G ratio was 0.55. A/G ratio > 0.55 was detected in 60 patients. Relative peak VO2 was lower in patients with A/G ratio > 0.55 than in patients with A/G ratio <0.55 (18.7 ± 5.3 vs. 22.5 ± 6.1 mL/kg/min, P < 0.001). Logistic regression analysis showed A/G ratio >0.55 to be independently associated with reduced peak VO2 adjusted for age, body mass index, LVEF, presence of sarcopenia, anabolic hormones, and haemoglobin (odds ratio 3.895, 95% confidence interval 1.030–14.730, P = 0.045). Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship. |
| format | Article |
| id | doaj-art-80ee47c8b1c64edc93e02901915accdf |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-80ee47c8b1c64edc93e02901915accdf2025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731101110810.1002/ehf2.12657Android to gynoid fat ratio and its association with functional capacity in male patients with heart failureMarcelo Rodrigues Dos Santos0Guilherme Wesley Peixoto daFonseca1Letícia Pironato Sherveninas2Francis Ribeiro deSouza3Antônio Carlos Battaglia Filho4Caio Eduardo Novaes5Rosa Maria Rodrigues Pereira6Carlos Eduardo Negrão7Antônio Carlos Pereira Barretto8Maria‐Janieire de Nazaré Nunes Alves9Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilLaboratório de Reumatologia e Metabolismo Ósseo da Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilInstituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo BrazilAbstract Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) <40%. Body composition (by using dual x‐ray absorptiometry) and peak VO2 (by cardiopulmonary exercise testing) were measured. Sarcopenic obesity was defined according to the Foundation for the National Institutes of Health criteria (FNIH). Blood sample for metabolic and hormonal parameters were measured. Fifteen patients (12.7%) showed sarcopenic obesity (body mass index > 25 kg/m2 with FNIH index < 0.789). The median A/G ratio was 0.55. A/G ratio > 0.55 was detected in 60 patients. Relative peak VO2 was lower in patients with A/G ratio > 0.55 than in patients with A/G ratio <0.55 (18.7 ± 5.3 vs. 22.5 ± 6.1 mL/kg/min, P < 0.001). Logistic regression analysis showed A/G ratio >0.55 to be independently associated with reduced peak VO2 adjusted for age, body mass index, LVEF, presence of sarcopenia, anabolic hormones, and haemoglobin (odds ratio 3.895, 95% confidence interval 1.030–14.730, P = 0.045). Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship.https://doi.org/10.1002/ehf2.12657Body compositionFat distributionHeart failureOxygen consumption |
| spellingShingle | Marcelo Rodrigues Dos Santos Guilherme Wesley Peixoto daFonseca Letícia Pironato Sherveninas Francis Ribeiro deSouza Antônio Carlos Battaglia Filho Caio Eduardo Novaes Rosa Maria Rodrigues Pereira Carlos Eduardo Negrão Antônio Carlos Pereira Barretto Maria‐Janieire de Nazaré Nunes Alves Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure ESC Heart Failure Body composition Fat distribution Heart failure Oxygen consumption |
| title | Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure |
| title_full | Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure |
| title_fullStr | Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure |
| title_full_unstemmed | Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure |
| title_short | Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure |
| title_sort | android to gynoid fat ratio and its association with functional capacity in male patients with heart failure |
| topic | Body composition Fat distribution Heart failure Oxygen consumption |
| url | https://doi.org/10.1002/ehf2.12657 |
| work_keys_str_mv | AT marcelorodriguesdossantos androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT guilhermewesleypeixotodafonseca androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT leticiapironatosherveninas androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT francisribeirodesouza androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT antoniocarlosbattagliafilho androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT caioeduardonovaes androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT rosamariarodriguespereira androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT carloseduardonegrao androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT antoniocarlospereirabarretto androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure AT mariajanieiredenazarenunesalves androidtogynoidfatratioanditsassociationwithfunctionalcapacityinmalepatientswithheartfailure |