Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction
Several studies have recognized the strong impact that the acute myocardial infarctions (AMI) have on the morbidity and mortality of patients affected by cardiovascular diseases. Still open, however, is the field concerning the mediators and the pathways involved in the etiology of this cardiovascul...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.45 |
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| _version_ | 1832552927767560192 |
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| author | Clara Di Filippo Francesco Rossi Michele D'Amico |
| author_facet | Clara Di Filippo Francesco Rossi Michele D'Amico |
| author_sort | Clara Di Filippo |
| collection | DOAJ |
| description | Several studies have recognized the strong impact that the acute myocardial infarctions (AMI) have on the morbidity and mortality of patients affected by cardiovascular diseases. Still open, however, is the field concerning the mediators and the pathways involved in the etiology of this cardiovascular event. The present review would support the relatively new discovered role that the polymorphonuclear leukocytes (PMNs) have in the pathogenesis of the AMI, through a brief analysis of past and ongoing research. Particularly, it is reviewed here the possibility that inhibition of the activity of PMNs and inhibition of the signaling pathways related to their activity may result useful in AMI and may improve the prognosis of this pathology. This review, indeed, presents and discusses new data on one of the lipid kinase, the phosphoinositide 3-kinase gamma (PI3Kγ), and its role in neutrophil recruitment during AMI. |
| format | Article |
| id | doaj-art-80df87c7d53048309e3fbf99de5fbe6d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-80df87c7d53048309e3fbf99de5fbe6d2025-02-03T05:57:32ZengWileyThe Scientific World Journal1537-744X2007-01-01712113410.1100/tsw.2007.45Targeting Polymorphonuclear Leukocytes in Acute Myocardial InfarctionClara Di Filippo0Francesco Rossi1Michele D'Amico2Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, 2nd University of Naples, Naples, ItalyDepartment of Experimental Medicine, Section of Pharmacology “L. Donatelli”, 2nd University of Naples, Naples, ItalyDepartment of Experimental Medicine, Section of Pharmacology “L. Donatelli”, 2nd University of Naples, Naples, ItalySeveral studies have recognized the strong impact that the acute myocardial infarctions (AMI) have on the morbidity and mortality of patients affected by cardiovascular diseases. Still open, however, is the field concerning the mediators and the pathways involved in the etiology of this cardiovascular event. The present review would support the relatively new discovered role that the polymorphonuclear leukocytes (PMNs) have in the pathogenesis of the AMI, through a brief analysis of past and ongoing research. Particularly, it is reviewed here the possibility that inhibition of the activity of PMNs and inhibition of the signaling pathways related to their activity may result useful in AMI and may improve the prognosis of this pathology. This review, indeed, presents and discusses new data on one of the lipid kinase, the phosphoinositide 3-kinase gamma (PI3Kγ), and its role in neutrophil recruitment during AMI.http://dx.doi.org/10.1100/tsw.2007.45 |
| spellingShingle | Clara Di Filippo Francesco Rossi Michele D'Amico Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction The Scientific World Journal |
| title | Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction |
| title_full | Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction |
| title_fullStr | Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction |
| title_full_unstemmed | Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction |
| title_short | Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction |
| title_sort | targeting polymorphonuclear leukocytes in acute myocardial infarction |
| url | http://dx.doi.org/10.1100/tsw.2007.45 |
| work_keys_str_mv | AT claradifilippo targetingpolymorphonuclearleukocytesinacutemyocardialinfarction AT francescorossi targetingpolymorphonuclearleukocytesinacutemyocardialinfarction AT micheledamico targetingpolymorphonuclearleukocytesinacutemyocardialinfarction |