Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental brain disorders in childhood. Despite extensive researches, the neurobiological mechanism underlying ADHD is still left unveiled. Since the deficit functions, such as attention, have been demonstrated in ADH...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6615384 |
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| author | Chunli Chen Huan Yang Yasong Du Guangzhi Zhai Hesheng Xiong Dezhong Yao Peng Xu Jianhua Gong Gang Yin Fali Li |
| author_facet | Chunli Chen Huan Yang Yasong Du Guangzhi Zhai Hesheng Xiong Dezhong Yao Peng Xu Jianhua Gong Gang Yin Fali Li |
| author_sort | Chunli Chen |
| collection | DOAJ |
| description | Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental brain disorders in childhood. Despite extensive researches, the neurobiological mechanism underlying ADHD is still left unveiled. Since the deficit functions, such as attention, have been demonstrated in ADHD, in our present study, based on the oddball P3 task, the corresponding electroencephalogram (EEG) of both healthy controls (HCs) and ADHD children was first collected. And we then not only focused on the event-related potential (ERP) evoked during tasks but also investigated related brain networks. Although an insignificant difference in behavior was found between the HCs and ADHD children, significant electrophysiological differences were found in both ERPs and brain networks. In detail, the dysfunctional attention occurred during the early stage of the designed task; as compared to HCs, the reduced P2 and N2 amplitudes in ADHD children were found, and the atypical information interaction might further underpin such a deficit. On the one hand, when investigating the cortical activity, HCs recruited much stronger brain activity mainly in the temporal and frontal regions, compared to ADHD children; on the other hand, the brain network showed atypical enhanced long-range connectivity between the frontal and occipital lobes but attenuated connectivity among frontal, parietal, and temporal lobes in ADHD children. We hope that the findings in this study may be instructive for the understanding of cognitive processing in children with ADHD. |
| format | Article |
| id | doaj-art-80d49a0cbe2e44ed8288799ea978ed64 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-80d49a0cbe2e44ed8288799ea978ed642025-02-03T01:29:20ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66153846615384Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP StudyChunli Chen0Huan Yang1Yasong Du2Guangzhi Zhai3Hesheng Xiong4Dezhong Yao5Peng Xu6Jianhua Gong7Gang Yin8Fali Li9School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha 410011, ChinaMental Health Center Affiliated to Medical School of Shanghai Jiao Tong University, 200030, ChinaShenzhen Nao Qianneng Co., Ltd., 518002, ChinaShenzhen Nao Qianneng Co., Ltd., 518002, ChinaSchool of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, ChinaSchool of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, ChinaLuohu District Maternity and Child Healthcare Hospital, Shenzhen 518019, ChinaSichuan Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, ChinaSchool of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 611731, ChinaAttention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental brain disorders in childhood. Despite extensive researches, the neurobiological mechanism underlying ADHD is still left unveiled. Since the deficit functions, such as attention, have been demonstrated in ADHD, in our present study, based on the oddball P3 task, the corresponding electroencephalogram (EEG) of both healthy controls (HCs) and ADHD children was first collected. And we then not only focused on the event-related potential (ERP) evoked during tasks but also investigated related brain networks. Although an insignificant difference in behavior was found between the HCs and ADHD children, significant electrophysiological differences were found in both ERPs and brain networks. In detail, the dysfunctional attention occurred during the early stage of the designed task; as compared to HCs, the reduced P2 and N2 amplitudes in ADHD children were found, and the atypical information interaction might further underpin such a deficit. On the one hand, when investigating the cortical activity, HCs recruited much stronger brain activity mainly in the temporal and frontal regions, compared to ADHD children; on the other hand, the brain network showed atypical enhanced long-range connectivity between the frontal and occipital lobes but attenuated connectivity among frontal, parietal, and temporal lobes in ADHD children. We hope that the findings in this study may be instructive for the understanding of cognitive processing in children with ADHD.http://dx.doi.org/10.1155/2021/6615384 |
| spellingShingle | Chunli Chen Huan Yang Yasong Du Guangzhi Zhai Hesheng Xiong Dezhong Yao Peng Xu Jianhua Gong Gang Yin Fali Li Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study Neural Plasticity |
| title | Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study |
| title_full | Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study |
| title_fullStr | Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study |
| title_full_unstemmed | Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study |
| title_short | Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study |
| title_sort | altered functional connectivity in children with adhd revealed by scalp eeg an erp study |
| url | http://dx.doi.org/10.1155/2021/6615384 |
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