Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study
ABSTRACT Hyperuricemia (HUA) is a metabolic abnormality syndrome caused by disorders of purine metabolism. This study aimed to investigate the predictive value of the low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio (LHR) for the risk of developing HUA. We extracted...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Clinical and Translational Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/cts.70122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589774247952384 |
|---|---|
| author | Yanyu Zhang Xiaoyi Liu Deyun Luo Bingli Chen Chenyi Lai Chenyu He Luo Yan Haifeng Ding Shiyang Li |
| author_facet | Yanyu Zhang Xiaoyi Liu Deyun Luo Bingli Chen Chenyi Lai Chenyu He Luo Yan Haifeng Ding Shiyang Li |
| author_sort | Yanyu Zhang |
| collection | DOAJ |
| description | ABSTRACT Hyperuricemia (HUA) is a metabolic abnormality syndrome caused by disorders of purine metabolism. This study aimed to investigate the predictive value of the low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio (LHR) for the risk of developing HUA. We extracted data from the China Health and Retirement Longitudinal Study (CHARLS) database from 2011 to 2016. Multivariable logistic regression, restricted cubic splines (RCSs) analysis, and linear correlation analysis were conducted to evaluate the association between LHR and risk of developing HUA. Subgroup analyses and interaction tests were also performed. A higher LHR was associated with an increased incidence of HUA (7.8% vs. 9.9% vs. 13.9, p < 0.001). The LHR was also higher in the HUA group compared to the non‐HUA group (2.64 ± 1.07 vs. 2.40 ± 0.91, p < 0.001). When assessed as a continuous variable, LHR was independently associated with the risk of HUA (OR = 1.27, 95% CI = 1.16–1.39, p < 0.001). The risk of developing HUA was significantly higher among individuals with the highest LHR subgroup than those with the lowest LHR subgroup (OR = 1.81, 95% CI = 1.47–2.23, p < 0.001). RCS analysis revealed a significant nonlinear association between an increased LHR and a higher risk of developing HUA. The predictive abilities of LHR for HUA were 0.577. The composite variable comprising LHR and other traditional risk factors could significantly enhance the ability to predict HUA (C statistic = 0.677). In conclusion, a higher LHR was associated with an increased risk of developing HUA. Further studies on LHR could be beneficial for preventing and treating HUA. |
| format | Article |
| id | doaj-art-80c845ae254546dd8702e13580edc369 |
| institution | Kabale University |
| issn | 1752-8054 1752-8062 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Science |
| spelling | doaj-art-80c845ae254546dd8702e13580edc3692025-01-24T08:17:46ZengWileyClinical and Translational Science1752-80541752-80622025-01-01181n/an/a10.1111/cts.70122Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort StudyYanyu Zhang0Xiaoyi Liu1Deyun Luo2Bingli Chen3Chenyi Lai4Chenyu He5Luo Yan6Haifeng Ding7Shiyang Li8Clinical Laboratory Panzhihua Central Hospital Panzhihua ChinaDepartment of Geriatrics Panzhihua Central Hospital Panzhihua ChinaDepartment of Geriatrics Panzhihua Central Hospital Panzhihua ChinaDepartment of Geriatrics Panzhihua Central Hospital Panzhihua ChinaDepartment of Geriatrics Panzhihua Central Hospital Panzhihua ChinaDepartment of Geriatrics Panzhihua Central Hospital Panzhihua ChinaHuaping County People's Hospital Lijiang City Yunnan Province ChinaDivision of Cardiology The First Affiliated Hospital of Shihezi University Shihezi ChinaDepartment of Geriatrics Panzhihua Central Hospital Panzhihua ChinaABSTRACT Hyperuricemia (HUA) is a metabolic abnormality syndrome caused by disorders of purine metabolism. This study aimed to investigate the predictive value of the low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio (LHR) for the risk of developing HUA. We extracted data from the China Health and Retirement Longitudinal Study (CHARLS) database from 2011 to 2016. Multivariable logistic regression, restricted cubic splines (RCSs) analysis, and linear correlation analysis were conducted to evaluate the association between LHR and risk of developing HUA. Subgroup analyses and interaction tests were also performed. A higher LHR was associated with an increased incidence of HUA (7.8% vs. 9.9% vs. 13.9, p < 0.001). The LHR was also higher in the HUA group compared to the non‐HUA group (2.64 ± 1.07 vs. 2.40 ± 0.91, p < 0.001). When assessed as a continuous variable, LHR was independently associated with the risk of HUA (OR = 1.27, 95% CI = 1.16–1.39, p < 0.001). The risk of developing HUA was significantly higher among individuals with the highest LHR subgroup than those with the lowest LHR subgroup (OR = 1.81, 95% CI = 1.47–2.23, p < 0.001). RCS analysis revealed a significant nonlinear association between an increased LHR and a higher risk of developing HUA. The predictive abilities of LHR for HUA were 0.577. The composite variable comprising LHR and other traditional risk factors could significantly enhance the ability to predict HUA (C statistic = 0.677). In conclusion, a higher LHR was associated with an increased risk of developing HUA. Further studies on LHR could be beneficial for preventing and treating HUA.https://doi.org/10.1111/cts.70122CHARLShyperuricemiaLHRnonlinear associationrisk |
| spellingShingle | Yanyu Zhang Xiaoyi Liu Deyun Luo Bingli Chen Chenyi Lai Chenyu He Luo Yan Haifeng Ding Shiyang Li Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study Clinical and Translational Science CHARLS hyperuricemia LHR nonlinear association risk |
| title | Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study |
| title_full | Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study |
| title_fullStr | Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study |
| title_full_unstemmed | Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study |
| title_short | Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study |
| title_sort | association of ldl c hdl c ratio with hyperuricemia a national cohort study |
| topic | CHARLS hyperuricemia LHR nonlinear association risk |
| url | https://doi.org/10.1111/cts.70122 |
| work_keys_str_mv | AT yanyuzhang associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT xiaoyiliu associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT deyunluo associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT binglichen associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT chenyilai associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT chenyuhe associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT luoyan associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT haifengding associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy AT shiyangli associationofldlchdlcratiowithhyperuricemiaanationalcohortstudy |