Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production

Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production

Abstract Fasting hypoglycemia is a severe and incompletely understood symptom of various inborn errors of metabolism (IEM). Precision-cut liver slices (PCLS) represent a promising model for studying glucose production ex vivo. This study quantified the net glucose production of human and murine PCLS...

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Main Authors: Ligia Akemi Kiyuna, Kishore Alagere Krishnamurthy, Esther B. Homan, Miriam Langelaar-Makkinje, Albert Gerding, Trijnie Bos, Dorenda Oosterhuis, Ruben J. Overduin, Andrea B. Schreuder, Vincent E. de Meijer, Peter Olinga, Terry G. J. Derks, Karen van Eunen, Barbara M. Bakker, Maaike H. Oosterveer
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07070-z
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