Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
The RNA-dependent RNA-polymerase, 3Dpol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3Dpol in mice has antiviral effects. Here, we discuss the structure and function of 3Dpol during picornavirus replication, we re...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2010/368068 |
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| _version_ | 1832560742658736128 |
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| author | Jason Kerkvliet Ramakrishna Edukulla Moses Rodriguez |
| author_facet | Jason Kerkvliet Ramakrishna Edukulla Moses Rodriguez |
| author_sort | Jason Kerkvliet |
| collection | DOAJ |
| description | The RNA-dependent RNA-polymerase, 3Dpol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3Dpol in mice has antiviral effects. Here, we discuss the structure and function of 3Dpol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3Dpol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3Dpol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3Dpol is causing this antiviral effect in mice. |
| format | Article |
| id | doaj-art-80ae56c1f4554f4197dbd149ec378a67 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-80ae56c1f4554f4197dbd149ec378a672025-02-03T01:26:49ZengWileyAdvances in Virology1687-86391687-86472010-01-01201010.1155/2010/368068368068Novel Roles of the Picornaviral 3D Polymerase in Viral PathogenesisJason Kerkvliet0Ramakrishna Edukulla1Moses Rodriguez2Department of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USAThe RNA-dependent RNA-polymerase, 3Dpol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3Dpol in mice has antiviral effects. Here, we discuss the structure and function of 3Dpol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3Dpol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3Dpol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3Dpol is causing this antiviral effect in mice.http://dx.doi.org/10.1155/2010/368068 |
| spellingShingle | Jason Kerkvliet Ramakrishna Edukulla Moses Rodriguez Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis Advances in Virology |
| title | Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis |
| title_full | Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis |
| title_fullStr | Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis |
| title_full_unstemmed | Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis |
| title_short | Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis |
| title_sort | novel roles of the picornaviral 3d polymerase in viral pathogenesis |
| url | http://dx.doi.org/10.1155/2010/368068 |
| work_keys_str_mv | AT jasonkerkvliet novelrolesofthepicornaviral3dpolymeraseinviralpathogenesis AT ramakrishnaedukulla novelrolesofthepicornaviral3dpolymeraseinviralpathogenesis AT mosesrodriguez novelrolesofthepicornaviral3dpolymeraseinviralpathogenesis |