Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition associated with various complications, including vascular ones. Platelet indices and vitamin D have been proposed as potential predictors of glycemic control deterioration and vascular complications in T2DM patients. This study aimed...
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PAGEPress Publications
2025-01-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/ijm/article/view/1875 |
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| author | Maryam Ahmed Obaid Al Ali Khalid Abdelsamea Mohamedahmed Asaad Ma Babker |
| author_facet | Maryam Ahmed Obaid Al Ali Khalid Abdelsamea Mohamedahmed Asaad Ma Babker |
| author_sort | Maryam Ahmed Obaid Al Ali |
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Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition associated with various complications, including vascular ones. Platelet indices and vitamin D have been proposed as potential predictors of glycemic control deterioration and vascular complications in T2DM patients. This study aimed to investigate the predictive role of platelet indices and vitamin D in the development of vascular complications and deterioration of glycemic control in type 2 diabetic patients attending Thumbay Hospital, Ajman. In this cross-sectional study, data were collected from individuals divided into two groups: a controlled group and a patient group with T2DM from the Thumbay Hospital and Thumbay Laboratory. A total of 100 individuals aged between 20 and 75 years was included. Demographic information, vitamin D levels, and platelet indices were collected and analyzed using appropriate statistical tests. The demographic distribution of T2DM patients revealed that males accounted for 56.76% of the sample, while females represented 43.22%. The analysis of vitamin D levels showed that 58% had a deficiency, 23% had an insufficiency, and 19% fell within the optimal range. Platelet indices were evaluated in relation to glycemic control, and significant associations were found between vitamin D levels and mean platelet volume (MPV) as well as platelet distribution width (PDW). Post-hoc tests indicated significant differences in plateletcrit values among specific glycemic control groups. Furthermore, diabetic patients had significantly higher levels of fasting blood glucose and hemoglobin A1C compared to the control group, along with higher MPV and slightly lower PDW. The findings suggest a potential predictive role of platelet indices and vitamin D in the deterioration of glycemic control and the development of vascular complications in T2DM patients attending Thumbay Hospital, Ajman.
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| format | Article |
| id | doaj-art-80682c7753d64550940529fb30c75b9a |
| institution | Kabale University |
| issn | 1877-9344 1877-9352 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Italian Journal of Medicine |
| spelling | doaj-art-80682c7753d64550940529fb30c75b9a2025-01-21T02:35:43ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522025-01-0119110.4081/itjm.2025.1875Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetesMaryam Ahmed Obaid Al Ali0Khalid Abdelsamea Mohamedahmed1Asaad Ma Babker2Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, AjmanDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Jordan; Department of Hematology and Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad MedaniDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition associated with various complications, including vascular ones. Platelet indices and vitamin D have been proposed as potential predictors of glycemic control deterioration and vascular complications in T2DM patients. This study aimed to investigate the predictive role of platelet indices and vitamin D in the development of vascular complications and deterioration of glycemic control in type 2 diabetic patients attending Thumbay Hospital, Ajman. In this cross-sectional study, data were collected from individuals divided into two groups: a controlled group and a patient group with T2DM from the Thumbay Hospital and Thumbay Laboratory. A total of 100 individuals aged between 20 and 75 years was included. Demographic information, vitamin D levels, and platelet indices were collected and analyzed using appropriate statistical tests. The demographic distribution of T2DM patients revealed that males accounted for 56.76% of the sample, while females represented 43.22%. The analysis of vitamin D levels showed that 58% had a deficiency, 23% had an insufficiency, and 19% fell within the optimal range. Platelet indices were evaluated in relation to glycemic control, and significant associations were found between vitamin D levels and mean platelet volume (MPV) as well as platelet distribution width (PDW). Post-hoc tests indicated significant differences in plateletcrit values among specific glycemic control groups. Furthermore, diabetic patients had significantly higher levels of fasting blood glucose and hemoglobin A1C compared to the control group, along with higher MPV and slightly lower PDW. The findings suggest a potential predictive role of platelet indices and vitamin D in the deterioration of glycemic control and the development of vascular complications in T2DM patients attending Thumbay Hospital, Ajman. https://www.italjmed.org/ijm/article/view/1875Diabetesplatelet indicesvitamin Dvascular complicationsglycemic control |
| spellingShingle | Maryam Ahmed Obaid Al Ali Khalid Abdelsamea Mohamedahmed Asaad Ma Babker Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes Italian Journal of Medicine Diabetes platelet indices vitamin D vascular complications glycemic control |
| title | Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes |
| title_full | Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes |
| title_fullStr | Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes |
| title_full_unstemmed | Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes |
| title_short | Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes |
| title_sort | role of platelet indices and vitamin d in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes |
| topic | Diabetes platelet indices vitamin D vascular complications glycemic control |
| url | https://www.italjmed.org/ijm/article/view/1875 |
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