Testosterone Deficiency, Cardiac Health, and Older Men

Low levels of testosterone are manifested by erectile dysfunction, reduced sexual desire, and loss of morning erections with increasing numbers of men are being diagnosed and require treatment. The prevalence rates of testosterone deficiency vary according to different studies but may be as high as...

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Main Authors: G. Hackett, M. Kirby, A. J. Sinclair
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2014/143763
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author G. Hackett
M. Kirby
A. J. Sinclair
author_facet G. Hackett
M. Kirby
A. J. Sinclair
author_sort G. Hackett
collection DOAJ
description Low levels of testosterone are manifested by erectile dysfunction, reduced sexual desire, and loss of morning erections with increasing numbers of men are being diagnosed and require treatment. The prevalence rates of testosterone deficiency vary according to different studies but may be as high as 40% in populations of patients with type 2 diabetes. There is increasing evidence that testosterone deficiency is associated with increased cardiovascular and all-cause mortality. Screening for low testosterone is recommended in a number of high risk groups including those with type 2 diabetes and metabolic syndrome. There are recent data to suggest that testosterone replacement therapy may reduce cardiovascular mortality as well as improving multiple surrogate markers for cardiovascular events. Specific clinical trials of testosterone replacement therapy are needed in selected populations but in the meantime we must treat patients based on the best current evidence.
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spelling doaj-art-804b0f06f7e54457987c20ed614632de2025-02-03T07:24:51ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/143763143763Testosterone Deficiency, Cardiac Health, and Older MenG. Hackett0M. Kirby1A. J. Sinclair2Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UKIDOP, University of Bedfordshire, Putteridge Bury Campus, Luton, Bedfordshire LU2 8LE, UKIDOP, University of Bedfordshire, Putteridge Bury Campus, Luton, Bedfordshire LU2 8LE, UKLow levels of testosterone are manifested by erectile dysfunction, reduced sexual desire, and loss of morning erections with increasing numbers of men are being diagnosed and require treatment. The prevalence rates of testosterone deficiency vary according to different studies but may be as high as 40% in populations of patients with type 2 diabetes. There is increasing evidence that testosterone deficiency is associated with increased cardiovascular and all-cause mortality. Screening for low testosterone is recommended in a number of high risk groups including those with type 2 diabetes and metabolic syndrome. There are recent data to suggest that testosterone replacement therapy may reduce cardiovascular mortality as well as improving multiple surrogate markers for cardiovascular events. Specific clinical trials of testosterone replacement therapy are needed in selected populations but in the meantime we must treat patients based on the best current evidence.http://dx.doi.org/10.1155/2014/143763
spellingShingle G. Hackett
M. Kirby
A. J. Sinclair
Testosterone Deficiency, Cardiac Health, and Older Men
International Journal of Endocrinology
title Testosterone Deficiency, Cardiac Health, and Older Men
title_full Testosterone Deficiency, Cardiac Health, and Older Men
title_fullStr Testosterone Deficiency, Cardiac Health, and Older Men
title_full_unstemmed Testosterone Deficiency, Cardiac Health, and Older Men
title_short Testosterone Deficiency, Cardiac Health, and Older Men
title_sort testosterone deficiency cardiac health and older men
url http://dx.doi.org/10.1155/2014/143763
work_keys_str_mv AT ghackett testosteronedeficiencycardiachealthandoldermen
AT mkirby testosteronedeficiencycardiachealthandoldermen
AT ajsinclair testosteronedeficiencycardiachealthandoldermen