Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model
Anagallis arvensis (A. arvensis) belonging to the family Primulaceae is traditionally used for liver and kidney diseases. The aim of the study was to evaluate the uroprotective and hepatoprotective potentials of A. arvensis in cyclophosphamide-induced interstitial cystitis and paracetamol-induced he...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/7241121 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562325545025536 |
|---|---|
| author | Ushna Shabbir Irfan Anjum Muhammad Naveed Mushtaq Muhammad Nasir Hayat Malik Sana Ismail Joham Javed Saeeda Noreen Ayesha Pervaiz Anika Tariq Misbah Wazir Zeenat Islam Muhammad Majid Sehrish Mansha Zaka Ur Rehman |
| author_facet | Ushna Shabbir Irfan Anjum Muhammad Naveed Mushtaq Muhammad Nasir Hayat Malik Sana Ismail Joham Javed Saeeda Noreen Ayesha Pervaiz Anika Tariq Misbah Wazir Zeenat Islam Muhammad Majid Sehrish Mansha Zaka Ur Rehman |
| author_sort | Ushna Shabbir |
| collection | DOAJ |
| description | Anagallis arvensis (A. arvensis) belonging to the family Primulaceae is traditionally used for liver and kidney diseases. The aim of the study was to evaluate the uroprotective and hepatoprotective potentials of A. arvensis in cyclophosphamide-induced interstitial cystitis and paracetamol-induced hepatotoxicity rat model, respectively. Nociception, bladder weight, vesical vascular permeability, Gray’s criteria for edema and hemorrhage, and levels of nitric oxide, catalase, and glutathione were estimated and studied in the cystitis model. Liver function test, lipid profile, and histopathological evaluation were carried out in the hepatoprotective activity. Oral administration of methanol extract of A. arvensis significantly reduced bladder weight, vesical vascular permeability, edema, hemorrhage, nitric oxide, IL-6, and TNF-α, while the level of catalase and glutathione peroxide was increased. In hepatoprotective activity, pretreatment with A. arvensis significantly decreased the level of liver markers (Bilirubin, ALT, AST, and ALP) and lipid profile (cholesterol, TG, LDL, and VLDL). Histopathological studies confirmed the biochemical findings of both studies. GC-MS analysis presented the presence of antioxidant phytoconstituents. Thus, it was concluded that A. arvensis might act as uroprotective and hepatoprotective due to the presence of antioxidant phytochemicals in the rodent model. Isolation and identification of phytochemicals present in the methanol extract of A. arvensis and evaluation of their exact mechanism of action become mandatory in future studies. |
| format | Article |
| id | doaj-art-8049511b309346c49cebc94ad851b700 |
| institution | Kabale University |
| issn | 1687-9694 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-8049511b309346c49cebc94ad851b7002025-02-03T01:22:53ZengWileyJournal of Tropical Medicine1687-96942022-01-01202210.1155/2022/7241121Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal ModelUshna Shabbir0Irfan Anjum1Muhammad Naveed Mushtaq2Muhammad Nasir Hayat Malik3Sana Ismail4Joham Javed5Saeeda Noreen6Ayesha Pervaiz7Anika Tariq8Misbah Wazir9Zeenat Islam10Muhammad Majid11Sehrish Mansha12Zaka Ur Rehman13Faculty of PharmacyFaculty of PharmacyFaculty of PharmacyFaculty of PharmacyFaculty of PharmacyLahore Pharmacy CollegeFaculty of PharmacyFaculty of PharmacyDepartment of Pharmacology and ToxicologyFaculty of PharmacyUniversity Institute of Diet & Nutritional SciencesFaculty of PharmacyFaculty of PharmacyFaculty of PharmacyAnagallis arvensis (A. arvensis) belonging to the family Primulaceae is traditionally used for liver and kidney diseases. The aim of the study was to evaluate the uroprotective and hepatoprotective potentials of A. arvensis in cyclophosphamide-induced interstitial cystitis and paracetamol-induced hepatotoxicity rat model, respectively. Nociception, bladder weight, vesical vascular permeability, Gray’s criteria for edema and hemorrhage, and levels of nitric oxide, catalase, and glutathione were estimated and studied in the cystitis model. Liver function test, lipid profile, and histopathological evaluation were carried out in the hepatoprotective activity. Oral administration of methanol extract of A. arvensis significantly reduced bladder weight, vesical vascular permeability, edema, hemorrhage, nitric oxide, IL-6, and TNF-α, while the level of catalase and glutathione peroxide was increased. In hepatoprotective activity, pretreatment with A. arvensis significantly decreased the level of liver markers (Bilirubin, ALT, AST, and ALP) and lipid profile (cholesterol, TG, LDL, and VLDL). Histopathological studies confirmed the biochemical findings of both studies. GC-MS analysis presented the presence of antioxidant phytoconstituents. Thus, it was concluded that A. arvensis might act as uroprotective and hepatoprotective due to the presence of antioxidant phytochemicals in the rodent model. Isolation and identification of phytochemicals present in the methanol extract of A. arvensis and evaluation of their exact mechanism of action become mandatory in future studies.http://dx.doi.org/10.1155/2022/7241121 |
| spellingShingle | Ushna Shabbir Irfan Anjum Muhammad Naveed Mushtaq Muhammad Nasir Hayat Malik Sana Ismail Joham Javed Saeeda Noreen Ayesha Pervaiz Anika Tariq Misbah Wazir Zeenat Islam Muhammad Majid Sehrish Mansha Zaka Ur Rehman Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model Journal of Tropical Medicine |
| title | Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model |
| title_full | Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model |
| title_fullStr | Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model |
| title_full_unstemmed | Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model |
| title_short | Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model |
| title_sort | uroprotective and hepatoprotective potential of anagallis arvensis against the experimental animal model |
| url | http://dx.doi.org/10.1155/2022/7241121 |
| work_keys_str_mv | AT ushnashabbir uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT irfananjum uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT muhammadnaveedmushtaq uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT muhammadnasirhayatmalik uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT sanaismail uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT johamjaved uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT saeedanoreen uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT ayeshapervaiz uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT anikatariq uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT misbahwazir uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT zeenatislam uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT muhammadmajid uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT sehrishmansha uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel AT zakaurrehman uroprotectiveandhepatoprotectivepotentialofanagallisarvensisagainsttheexperimentalanimalmodel |