Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy
Chiral amino acids play an indispensable role in living organisms. Diffusion-ordered NMR spectroscopy is an effective NMR tool and a noninvasive analytical method for the analyses of mixture without the need for physical separation of the analytes. However, conventional diffusion-ordered NMR spectro...
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Elsevier
2025-03-01
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| Series: | Journal of Magnetic Resonance Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666441025000056 |
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| author | Bowen Han Jing He Shaohua Huang |
| author_facet | Bowen Han Jing He Shaohua Huang |
| author_sort | Bowen Han |
| collection | DOAJ |
| description | Chiral amino acids play an indispensable role in living organisms. Diffusion-ordered NMR spectroscopy is an effective NMR tool and a noninvasive analytical method for the analyses of mixture without the need for physical separation of the analytes. However, conventional diffusion-ordered NMR spectroscopy method usually fails to resolve the mixtures of chiral amino acids because of their same molecular masses, sizes, and shapes. Microcrystalline cellulose has been gradually gained more and more interest owing to its wide compatibility, surface area, excellent separation efficiency, non-toxicity, cost-effective, and mechanical stability in many fields. Herein we provide a fast, simple, specific and sensitive method to resolve some D and L-amino acids mixtures by using microcrystalline cellulose as a matrix. This work recognized some D and L- proteinogenic amino acid enantiomers with diffusion-ordered NMR for the first time. |
| format | Article |
| id | doaj-art-8048b6988e144a7faf2102584c068d2f |
| institution | Kabale University |
| issn | 2666-4410 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Magnetic Resonance Open |
| spelling | doaj-art-8048b6988e144a7faf2102584c068d2f2025-02-05T04:32:41ZengElsevierJournal of Magnetic Resonance Open2666-44102025-03-0122100189Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopyBowen Han0Jing He1Shaohua Huang2Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, PR ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, PR China; School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073, PR ChinaInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, PR China; Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang, PR China; Corresponding author at: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, PR China.Chiral amino acids play an indispensable role in living organisms. Diffusion-ordered NMR spectroscopy is an effective NMR tool and a noninvasive analytical method for the analyses of mixture without the need for physical separation of the analytes. However, conventional diffusion-ordered NMR spectroscopy method usually fails to resolve the mixtures of chiral amino acids because of their same molecular masses, sizes, and shapes. Microcrystalline cellulose has been gradually gained more and more interest owing to its wide compatibility, surface area, excellent separation efficiency, non-toxicity, cost-effective, and mechanical stability in many fields. Herein we provide a fast, simple, specific and sensitive method to resolve some D and L-amino acids mixtures by using microcrystalline cellulose as a matrix. This work recognized some D and L- proteinogenic amino acid enantiomers with diffusion-ordered NMR for the first time.http://www.sciencedirect.com/science/article/pii/S2666441025000056Diffusion-ordered NMRMatrixMicrocrystalline celluloseD/L-amino acidsSeparation |
| spellingShingle | Bowen Han Jing He Shaohua Huang Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy Journal of Magnetic Resonance Open Diffusion-ordered NMR Matrix Microcrystalline cellulose D/L-amino acids Separation |
| title | Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy |
| title_full | Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy |
| title_fullStr | Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy |
| title_full_unstemmed | Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy |
| title_short | Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy |
| title_sort | chiral recognition of some d and l amino acids by microcrystalline cellulose assisted diffusion ordered nmr spectroscopy |
| topic | Diffusion-ordered NMR Matrix Microcrystalline cellulose D/L-amino acids Separation |
| url | http://www.sciencedirect.com/science/article/pii/S2666441025000056 |
| work_keys_str_mv | AT bowenhan chiralrecognitionofsomedandlaminoacidsbymicrocrystallinecelluloseassisteddiffusionorderednmrspectroscopy AT jinghe chiralrecognitionofsomedandlaminoacidsbymicrocrystallinecelluloseassisteddiffusionorderednmrspectroscopy AT shaohuahuang chiralrecognitionofsomedandlaminoacidsbymicrocrystallinecelluloseassisteddiffusionorderednmrspectroscopy |