Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients
Calciphylaxis, or calcification uremic arteriolopathy, is a rare disease thought to occur due to arteriolar calcifications of the dermis and is responsible for ischemia with cutaneous necrosis and painful panniculitis. Its mechanism remains poorly understood which makes its management challenging an...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2019/1630613 |
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| _version_ | 1832545794725511168 |
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| author | Ibtissam Fares Tarik Bouattar Hadja Moussokoro Kone Hajar Benzouina Meryem Benbella Naima Ouzeddoun Rabia Bayahia Loubna Benamar |
| author_facet | Ibtissam Fares Tarik Bouattar Hadja Moussokoro Kone Hajar Benzouina Meryem Benbella Naima Ouzeddoun Rabia Bayahia Loubna Benamar |
| author_sort | Ibtissam Fares |
| collection | DOAJ |
| description | Calciphylaxis, or calcification uremic arteriolopathy, is a rare disease thought to occur due to arteriolar calcifications of the dermis and is responsible for ischemia with cutaneous necrosis and painful panniculitis. Its mechanism remains poorly understood which makes its management challenging and difficult to standardize. We report our management of two patients diagnosed with calciphylaxis. In one patient, calciphylaxis was mentioned upon admission given the context of preexisting secondary hyperparathyroidism and the existence of multiple risk factors. In both patients, the diagnosis was confirmed histologically. Our two observations highlight the difficulty of the diagnosis and the complexity of the therapeutic management that has been personalized according to patient characteristics and clinical evolution. Several therapeutic means can be implemented once the diagnosis is made; nevertheless, its prognosis remains pejorative despite the therapeutic advances. Broad debridement, good phosphocalcic balance control, and the correction of the risk factors top the list of any therapeutic strategy. One of the major challenges of the therapy is normalizing the calcium-phosphate balance. Thus, Cinacalcet and sodium thiosulfate appear to be promising treatments. |
| format | Article |
| id | doaj-art-80460efded0946539c01d2cca6c62d5b |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-80460efded0946539c01d2cca6c62d5b2025-02-03T07:24:45ZengWileyCase Reports in Nephrology2090-66412090-665X2019-01-01201910.1155/2019/16306131630613Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two PatientsIbtissam Fares0Tarik Bouattar1Hadja Moussokoro Kone2Hajar Benzouina3Meryem Benbella4Naima Ouzeddoun5Rabia Bayahia6Loubna Benamar7Nephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoNephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, MoroccoCalciphylaxis, or calcification uremic arteriolopathy, is a rare disease thought to occur due to arteriolar calcifications of the dermis and is responsible for ischemia with cutaneous necrosis and painful panniculitis. Its mechanism remains poorly understood which makes its management challenging and difficult to standardize. We report our management of two patients diagnosed with calciphylaxis. In one patient, calciphylaxis was mentioned upon admission given the context of preexisting secondary hyperparathyroidism and the existence of multiple risk factors. In both patients, the diagnosis was confirmed histologically. Our two observations highlight the difficulty of the diagnosis and the complexity of the therapeutic management that has been personalized according to patient characteristics and clinical evolution. Several therapeutic means can be implemented once the diagnosis is made; nevertheless, its prognosis remains pejorative despite the therapeutic advances. Broad debridement, good phosphocalcic balance control, and the correction of the risk factors top the list of any therapeutic strategy. One of the major challenges of the therapy is normalizing the calcium-phosphate balance. Thus, Cinacalcet and sodium thiosulfate appear to be promising treatments.http://dx.doi.org/10.1155/2019/1630613 |
| spellingShingle | Ibtissam Fares Tarik Bouattar Hadja Moussokoro Kone Hajar Benzouina Meryem Benbella Naima Ouzeddoun Rabia Bayahia Loubna Benamar Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients Case Reports in Nephrology |
| title | Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients |
| title_full | Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients |
| title_fullStr | Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients |
| title_full_unstemmed | Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients |
| title_short | Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients |
| title_sort | calciphylaxis successful management of a rare complication of chronic kidney disease in two patients |
| url | http://dx.doi.org/10.1155/2019/1630613 |
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