Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles
ObjectiveOvarian cancer is one of the most lethal gynecological malignancies. This study aimed to evaluate the prognostic significance of complete blood count (CBC) and lipid profile in patients with optimally debulked epithelial ovarian cancer (EOC) and develop a nomogram model to predict recurrenc...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525867/full |
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| author | Xi Tang Jingke He Qin Huang Yi Chen Ke Chen Jing Liu Yingyu Tian Hui Wang |
| author_facet | Xi Tang Jingke He Qin Huang Yi Chen Ke Chen Jing Liu Yingyu Tian Hui Wang |
| author_sort | Xi Tang |
| collection | DOAJ |
| description | ObjectiveOvarian cancer is one of the most lethal gynecological malignancies. This study aimed to evaluate the prognostic significance of complete blood count (CBC) and lipid profile in patients with optimally debulked epithelial ovarian cancer (EOC) and develop a nomogram model to predict recurrence-free survival (RFS).MethodsThis retrospective study analyzed patients diagnosed with EOC between January 2018 and June 2022.ResultsA total of 307 patients were randomly divided into training and validation sets in a ratio of 7:3. Grade, International Federation of Gynecology and Obstetrics (FIGO) stage, platelet-to-lymphocyte ratio, red blood cell distribution width-coefficient of variation, triglycerides, and human epididymal protein 4 were identified as independent prognostic factors. The novel nomogram displayed a good predictive performance, with a concordance index (C-index) of 0.787 in the training group and 0.807 in the validation group. The areas under the curve for 1-, 3-, and 5-year RFS were 0.770, 0.881, and 0.904, respectively, in the training group, and 0.667, 0.906, and 0.886, respectively, in the validation group. The calibration curves exhibited good concordance between the predicted survival probabilities and actual observations. Time-dependent C-index curves, integrated discrimination improvement, net reclassification index, and decision curve analysis showed that the nomogram outperformed FIGO staging.ConclusionThis study established and validated a nomogram combining CBC and lipid profiles to predict RFS in patients with optimally debulked EOC, which is expected to aid gynecologists in individualized prognosis assessment and clinical management. |
| format | Article |
| id | doaj-art-8038ad2e9e164bbe9494f2ccba907f28 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-8038ad2e9e164bbe9494f2ccba907f282025-02-03T05:11:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15258671525867Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profilesXi Tang0Jingke He1Qin Huang2Yi Chen3Ke Chen4Jing Liu5Yingyu Tian6Hui Wang7Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjectiveOvarian cancer is one of the most lethal gynecological malignancies. This study aimed to evaluate the prognostic significance of complete blood count (CBC) and lipid profile in patients with optimally debulked epithelial ovarian cancer (EOC) and develop a nomogram model to predict recurrence-free survival (RFS).MethodsThis retrospective study analyzed patients diagnosed with EOC between January 2018 and June 2022.ResultsA total of 307 patients were randomly divided into training and validation sets in a ratio of 7:3. Grade, International Federation of Gynecology and Obstetrics (FIGO) stage, platelet-to-lymphocyte ratio, red blood cell distribution width-coefficient of variation, triglycerides, and human epididymal protein 4 were identified as independent prognostic factors. The novel nomogram displayed a good predictive performance, with a concordance index (C-index) of 0.787 in the training group and 0.807 in the validation group. The areas under the curve for 1-, 3-, and 5-year RFS were 0.770, 0.881, and 0.904, respectively, in the training group, and 0.667, 0.906, and 0.886, respectively, in the validation group. The calibration curves exhibited good concordance between the predicted survival probabilities and actual observations. Time-dependent C-index curves, integrated discrimination improvement, net reclassification index, and decision curve analysis showed that the nomogram outperformed FIGO staging.ConclusionThis study established and validated a nomogram combining CBC and lipid profiles to predict RFS in patients with optimally debulked EOC, which is expected to aid gynecologists in individualized prognosis assessment and clinical management.https://www.frontiersin.org/articles/10.3389/fonc.2025.1525867/fullnomogramepithelial ovarian cancerrecurrencecomplete blood countlipid profile |
| spellingShingle | Xi Tang Jingke He Qin Huang Yi Chen Ke Chen Jing Liu Yingyu Tian Hui Wang Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles Frontiers in Oncology nomogram epithelial ovarian cancer recurrence complete blood count lipid profile |
| title | Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles |
| title_full | Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles |
| title_fullStr | Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles |
| title_full_unstemmed | Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles |
| title_short | Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles |
| title_sort | development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles |
| topic | nomogram epithelial ovarian cancer recurrence complete blood count lipid profile |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525867/full |
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