Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia
Maternofetal immune tolerance is essential to maintain pregnancy. The maternal immunological tolerance to the semiallogeneic fetus becomes greater in egg donation pregnancies with unrelated donors as the complete fetal genome is allogeneic to the mother. Instead of being rejected, the allogeneic fet...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/210241 |
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| author | Alicia Martínez-Varea Begoña Pellicer Alfredo Perales-Marín Antonio Pellicer |
| author_facet | Alicia Martínez-Varea Begoña Pellicer Alfredo Perales-Marín Antonio Pellicer |
| author_sort | Alicia Martínez-Varea |
| collection | DOAJ |
| description | Maternofetal immune tolerance is essential to maintain pregnancy. The maternal immunological tolerance to the semiallogeneic fetus becomes greater in egg donation pregnancies with unrelated donors as the complete fetal genome is allogeneic to the mother. Instead of being rejected, the allogeneic fetus is tolerated by the pregnant woman in egg donation pregnancies. It has been reported that maternal morbidity during egg donation pregnancies is higher as compared with spontaneous or in vitro fertilization pregnancies. Particularly, egg donation pregnancies are associated with a higher incidence of pregnancy-induced hypertension and placental pathology. Preeclampsia, a pregnancy-specific disease characterized by the development of both hypertension and proteinuria, remains the leading cause of maternal and perinatal mortality and morbidity. The aim of this review is to characterize and relate the maternofetal immunological tolerance phenomenon during pregnancies with a semiallogenic fetus, which are the spontaneously conceived pregnancies and in vitro fertilization pregnancies, and those with an allogeneic fetus or egg donation pregnancies. Maternofetal immune tolerance in uncomplicated pregnancies and pathological pregnancies, such as those with preeclampsia, has also been assessed. Moreover, whether an inadequate maternal immunological response to the allogenic fetus could lead to a higher prevalence of preeclampsia in egg donation pregnancies has been addressed. |
| format | Article |
| id | doaj-art-802d2ea61b7e41df8d311659f7caf897 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-802d2ea61b7e41df8d311659f7caf8972025-02-03T01:28:47ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/210241210241Relationship between Maternal Immunological Response during Pregnancy and Onset of PreeclampsiaAlicia Martínez-Varea0Begoña Pellicer1Alfredo Perales-Marín2Antonio Pellicer3Department of Obstetrics and Gynecology, Hospital Universitario y Politécnico La Fe, Avenida Bulevar Sur s/n, Valencia 46026, SpainDepartment of Obstetrics and Gynecology, Hospital General Universitario, Avenida Tres Cruces 2, Valencia 46014, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario y Politécnico La Fe, Avenida Bulevar Sur s/n, Valencia 46026, SpainDepartment of Obstetrics and Gynecology, Hospital Universitario y Politécnico La Fe, Avenida Bulevar Sur s/n, Valencia 46026, SpainMaternofetal immune tolerance is essential to maintain pregnancy. The maternal immunological tolerance to the semiallogeneic fetus becomes greater in egg donation pregnancies with unrelated donors as the complete fetal genome is allogeneic to the mother. Instead of being rejected, the allogeneic fetus is tolerated by the pregnant woman in egg donation pregnancies. It has been reported that maternal morbidity during egg donation pregnancies is higher as compared with spontaneous or in vitro fertilization pregnancies. Particularly, egg donation pregnancies are associated with a higher incidence of pregnancy-induced hypertension and placental pathology. Preeclampsia, a pregnancy-specific disease characterized by the development of both hypertension and proteinuria, remains the leading cause of maternal and perinatal mortality and morbidity. The aim of this review is to characterize and relate the maternofetal immunological tolerance phenomenon during pregnancies with a semiallogenic fetus, which are the spontaneously conceived pregnancies and in vitro fertilization pregnancies, and those with an allogeneic fetus or egg donation pregnancies. Maternofetal immune tolerance in uncomplicated pregnancies and pathological pregnancies, such as those with preeclampsia, has also been assessed. Moreover, whether an inadequate maternal immunological response to the allogenic fetus could lead to a higher prevalence of preeclampsia in egg donation pregnancies has been addressed.http://dx.doi.org/10.1155/2014/210241 |
| spellingShingle | Alicia Martínez-Varea Begoña Pellicer Alfredo Perales-Marín Antonio Pellicer Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia Journal of Immunology Research |
| title | Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia |
| title_full | Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia |
| title_fullStr | Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia |
| title_full_unstemmed | Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia |
| title_short | Relationship between Maternal Immunological Response during Pregnancy and Onset of Preeclampsia |
| title_sort | relationship between maternal immunological response during pregnancy and onset of preeclampsia |
| url | http://dx.doi.org/10.1155/2014/210241 |
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