Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China
This study was to investigate the antibiotic resistance profile of H. pylori and the distribution of CYP2C19 gene polymorphism in rural population of Chongqing, China. 214 and 111 strains of H. pylori were isolated from rural and urban patients, respectively. 99.53%, 20.09%, and 23.36% of the isolat...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/8547686 |
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| author | Ran Han Hong Lu Ming-Wan Jiang Ke-Wen Tan Zhong Peng Jia-Li Hu Dian-Chun Fang Chun-Hui Lan Xiao-Ling Wu |
| author_facet | Ran Han Hong Lu Ming-Wan Jiang Ke-Wen Tan Zhong Peng Jia-Li Hu Dian-Chun Fang Chun-Hui Lan Xiao-Ling Wu |
| author_sort | Ran Han |
| collection | DOAJ |
| description | This study was to investigate the antibiotic resistance profile of H. pylori and the distribution of CYP2C19 gene polymorphism in rural population of Chongqing, China. 214 and 111 strains of H. pylori were isolated from rural and urban patients, respectively. 99.53%, 20.09%, and 23.36% of the isolates in rural patients were found to be resistant to metronidazole, clarithromycin, and levofloxacin, while the resistant rate in urban patients was 82.88%, 19.82%, and 24.32%. The multiple antibiotic resistance percentage significantly increased from 28.26% (below 45 years) to 41.80% (above 45 years) in rural patients. Up to 44.39%, 45.79%, and 9.81% of rural patients from whom H. pylori was isolated were found to be extensive metabolizers, intermediate metabolizers, and poor metabolizers. No correlation was observed between antibiotic resistance profile of H. pylori and genetic polymorphism of CYP2C19 among rural population. There was a high prevalence of H. pylori strains resistant to metronidazole, clarithromycin, and levofloxacin in rural patients in Chongqing, China. The choice of therapy in this area should be based on local susceptibility patterns. Amoxicillin, gentamicin, and furazolidone are recommended as the first-line empiric regimen. |
| format | Article |
| id | doaj-art-801bbefcdc45445ca125018fac61f86d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-801bbefcdc45445ca125018fac61f86d2025-02-03T01:11:00ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/85476868547686Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, ChinaRan Han0Hong Lu1Ming-Wan Jiang2Ke-Wen Tan3Zhong Peng4Jia-Li Hu5Dian-Chun Fang6Chun-Hui Lan7Xiao-Ling Wu8The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Gastroenterology, Changshou District People’s Hospital, Chongqing 400016, ChinaDepartment of Gastroenterology, Sanxia Central Hospital, Chongqing 400016, ChinaDepartment of Gastroenterology, Dianjiang County People’s Hospital, Chongqing 400016, ChinaDepartment of Gastroenterology, Qijiang County People’s Hospital, Chongqing 400016, ChinaDepartment of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400016, ChinaDepartment of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400016, ChinaDepartment of Gastroenterology, Daping Hospital, Third Military Medical University, Chongqing 400042, ChinaThe Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaThis study was to investigate the antibiotic resistance profile of H. pylori and the distribution of CYP2C19 gene polymorphism in rural population of Chongqing, China. 214 and 111 strains of H. pylori were isolated from rural and urban patients, respectively. 99.53%, 20.09%, and 23.36% of the isolates in rural patients were found to be resistant to metronidazole, clarithromycin, and levofloxacin, while the resistant rate in urban patients was 82.88%, 19.82%, and 24.32%. The multiple antibiotic resistance percentage significantly increased from 28.26% (below 45 years) to 41.80% (above 45 years) in rural patients. Up to 44.39%, 45.79%, and 9.81% of rural patients from whom H. pylori was isolated were found to be extensive metabolizers, intermediate metabolizers, and poor metabolizers. No correlation was observed between antibiotic resistance profile of H. pylori and genetic polymorphism of CYP2C19 among rural population. There was a high prevalence of H. pylori strains resistant to metronidazole, clarithromycin, and levofloxacin in rural patients in Chongqing, China. The choice of therapy in this area should be based on local susceptibility patterns. Amoxicillin, gentamicin, and furazolidone are recommended as the first-line empiric regimen.http://dx.doi.org/10.1155/2016/8547686 |
| spellingShingle | Ran Han Hong Lu Ming-Wan Jiang Ke-Wen Tan Zhong Peng Jia-Li Hu Dian-Chun Fang Chun-Hui Lan Xiao-Ling Wu Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China Gastroenterology Research and Practice |
| title | Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China |
| title_full | Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China |
| title_fullStr | Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China |
| title_full_unstemmed | Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China |
| title_short | Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China |
| title_sort | multicenter study of antibiotic resistance profile of h pylori and distribution of cyp2c19 gene polymorphism in rural population of chongqing china |
| url | http://dx.doi.org/10.1155/2016/8547686 |
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