Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS
Background. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs. However, little information is available about sequelae following DIHS/DRESS resolution from an endocrinologist’s perspective....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/7959615 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551611861303296 |
|---|---|
| author | Mingqun Deng Han Wu Miao Yu Yi Tian Yuxiu Li Xinhua Xiao |
| author_facet | Mingqun Deng Han Wu Miao Yu Yi Tian Yuxiu Li Xinhua Xiao |
| author_sort | Mingqun Deng |
| collection | DOAJ |
| description | Background. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs. However, little information is available about sequelae following DIHS/DRESS resolution from an endocrinologist’s perspective. This study aimed to investigate the endocrine sequelae following DIHS/DRESS, from clinical feature to etiology. Methods. We retrospectively analyzed the patients diagnosed with DIHS/DRESS in Peking Union Medical College Hospital (PUMCH) during the period of 1 January 2012 to 31 December 2017, and those who developed endocrine disorders after DIHS/DRESS were further examined. We also reviewed the literature, from 1 January 2000 to 31 December 2017, on involvement of endocrine glands in DIHS/DRESS patients. Results. Three patients developed both autoimmune thyroid disease (AITD) and type 1 diabetes (T1DM)/fulminant type 1 diabetes (FT1DM) of the 45 patients. Seven cases involving more than two endocrine glands were reported in the literature. Our results indicated that DIHS/DRESS is a potential etiological factor of autoimmune polyendocrine syndrome (APS), especially APS III. Conclusions. Patients require careful long-term follow-up after DIHS/DRESS. Involvement of endocrine glands, especially FT1DM, should always be monitored in patients with a history of DIHS/DRESS. This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS. |
| format | Article |
| id | doaj-art-801b6b6187cc4eeabefc8626d07b12ac |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-801b6b6187cc4eeabefc8626d07b12ac2025-02-03T06:00:58ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/79596157959615Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESSMingqun Deng0Han Wu1Miao Yu2Yi Tian3Yuxiu Li4Xinhua Xiao5Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaBackground. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs. However, little information is available about sequelae following DIHS/DRESS resolution from an endocrinologist’s perspective. This study aimed to investigate the endocrine sequelae following DIHS/DRESS, from clinical feature to etiology. Methods. We retrospectively analyzed the patients diagnosed with DIHS/DRESS in Peking Union Medical College Hospital (PUMCH) during the period of 1 January 2012 to 31 December 2017, and those who developed endocrine disorders after DIHS/DRESS were further examined. We also reviewed the literature, from 1 January 2000 to 31 December 2017, on involvement of endocrine glands in DIHS/DRESS patients. Results. Three patients developed both autoimmune thyroid disease (AITD) and type 1 diabetes (T1DM)/fulminant type 1 diabetes (FT1DM) of the 45 patients. Seven cases involving more than two endocrine glands were reported in the literature. Our results indicated that DIHS/DRESS is a potential etiological factor of autoimmune polyendocrine syndrome (APS), especially APS III. Conclusions. Patients require careful long-term follow-up after DIHS/DRESS. Involvement of endocrine glands, especially FT1DM, should always be monitored in patients with a history of DIHS/DRESS. This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS.http://dx.doi.org/10.1155/2019/7959615 |
| spellingShingle | Mingqun Deng Han Wu Miao Yu Yi Tian Yuxiu Li Xinhua Xiao Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS International Journal of Endocrinology |
| title | Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS |
| title_full | Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS |
| title_fullStr | Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS |
| title_full_unstemmed | Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS |
| title_short | Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS |
| title_sort | co occurrence of multiple endocrine abnormalities induced by the dihs dress |
| url | http://dx.doi.org/10.1155/2019/7959615 |
| work_keys_str_mv | AT mingqundeng cooccurrenceofmultipleendocrineabnormalitiesinducedbythedihsdress AT hanwu cooccurrenceofmultipleendocrineabnormalitiesinducedbythedihsdress AT miaoyu cooccurrenceofmultipleendocrineabnormalitiesinducedbythedihsdress AT yitian cooccurrenceofmultipleendocrineabnormalitiesinducedbythedihsdress AT yuxiuli cooccurrenceofmultipleendocrineabnormalitiesinducedbythedihsdress AT xinhuaxiao cooccurrenceofmultipleendocrineabnormalitiesinducedbythedihsdress |