Proximity Labeling-Based Identification of MGAT3 Substrates and Revelation of the Tumor-Suppressive Role of Bisecting GlcNAc in Breast Cancer via GLA Degradation
Glycosylation plays a critical role in various biological processes, yet identifying specific glycosyltransferase substrates remains a challenge due to the complexity of glycosylation. Here, we employ proximity labeling with biotin ligases BASU and TurboID to map the proximitome of MGAT3, a glycosyl...
Saved in:
Main Authors: | Bowen Wang, Xin He, Yue Zhou, Zengqi Tan, Xiang Li, Feng Guan, Lei Lei |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2025-01-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/14/2/103 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis
by: Jing Li, et al.
Published: (2025-01-01) -
MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB
by: Yihan Ma, et al.
Published: (2025-01-01) -
O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury
by: Zhichao Zeng, et al.
Published: (2025-03-01) -
O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation
by: Junjie Gou, et al.
Published: (2025-01-01) -
Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation
by: Donghyun Kang, et al.
Published: (2025-02-01)