Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine
Considering that nicotine instantly interacts with central and peripheral nervous systems promoting cardiovascular effects after tobacco smoking, we evaluated the modulation of glutamate, tyrosine hydroxylase (TH), neuropeptide Y (NPY), and substance P (SP) in nodose/petrosal and superior cervical g...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/216464 |
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| author | Merari F. R. Ferrari Emerson F. Coelho Karen L. G. Farizatto Gerson Chadi Debora R. Fior-Chadi |
| author_facet | Merari F. R. Ferrari Emerson F. Coelho Karen L. G. Farizatto Gerson Chadi Debora R. Fior-Chadi |
| author_sort | Merari F. R. Ferrari |
| collection | DOAJ |
| description | Considering that nicotine instantly interacts with central and peripheral nervous systems promoting cardiovascular effects after tobacco smoking, we evaluated the modulation of glutamate, tyrosine hydroxylase (TH), neuropeptide Y (NPY), and substance P (SP) in nodose/petrosal and superior cervical ganglia, as well as TH and NPY in nucleus tractus solitarii (NTS) and hypothalamic paraventricular nucleus (PVN) of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) after 8 weeks of nicotine exposure. Immunohistochemical and in situ hybridization data demonstrated increased expression of TH in brain and ganglia related to blood pressure control, preferentially in SHR, after nicotine exposure. The alkaloid also increased NPY immunoreactivity in ganglia, NTS, and PVN of SHR, in spite of decreasing its receptor (NPY1R) binding in NTS of both strains. Nicotine increased SP and glutamate in ganglia. In summary, nicotine positively modulated the studied variables in ganglia while its central effects were mainly constrained to SHR. |
| format | Article |
| id | doaj-art-800bd23d10174b209f68dc4910207581 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-800bd23d10174b209f68dc49102075812025-02-03T06:11:59ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/216464216464Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to NicotineMerari F. R. Ferrari0Emerson F. Coelho1Karen L. G. Farizatto2Gerson Chadi3Debora R. Fior-Chadi4Departamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de São Paulo, Rua do Matao 277, 05508-090 São Paulo, SP, BrazilDepartamento de Fisiologia, Instituto de Biociencias, Universidade de São Paulo, 05508-090 São Paulo, SP, BrazilDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de São Paulo, Rua do Matao 277, 05508-090 São Paulo, SP, BrazilDepartamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, 01246-903 São Paulo, SP, BrazilDepartamento de Fisiologia, Instituto de Biociencias, Universidade de São Paulo, 05508-090 São Paulo, SP, BrazilConsidering that nicotine instantly interacts with central and peripheral nervous systems promoting cardiovascular effects after tobacco smoking, we evaluated the modulation of glutamate, tyrosine hydroxylase (TH), neuropeptide Y (NPY), and substance P (SP) in nodose/petrosal and superior cervical ganglia, as well as TH and NPY in nucleus tractus solitarii (NTS) and hypothalamic paraventricular nucleus (PVN) of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) after 8 weeks of nicotine exposure. Immunohistochemical and in situ hybridization data demonstrated increased expression of TH in brain and ganglia related to blood pressure control, preferentially in SHR, after nicotine exposure. The alkaloid also increased NPY immunoreactivity in ganglia, NTS, and PVN of SHR, in spite of decreasing its receptor (NPY1R) binding in NTS of both strains. Nicotine increased SP and glutamate in ganglia. In summary, nicotine positively modulated the studied variables in ganglia while its central effects were mainly constrained to SHR.http://dx.doi.org/10.4061/2011/216464 |
| spellingShingle | Merari F. R. Ferrari Emerson F. Coelho Karen L. G. Farizatto Gerson Chadi Debora R. Fior-Chadi Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine International Journal of Hypertension |
| title | Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine |
| title_full | Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine |
| title_fullStr | Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine |
| title_full_unstemmed | Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine |
| title_short | Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine |
| title_sort | modulation of tyrosine hydroxylase neuropeptide y glutamate and substance p in ganglia and brain areas involved in cardiovascular control after chronic exposure to nicotine |
| url | http://dx.doi.org/10.4061/2011/216464 |
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