Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization

Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization

Abstract Background The triple-negative subtype of breast cancer is particularly challenging to treat due to its aggressiveness with a high risk of brain metastasis, and the lack of effective targeted therapies. Tubulin beta 2B class IIb (TUBB2B), a β-tubulin isoform regulating axon guidance during...

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Bibliographic Details
Main Authors: Qingling He, Jianyang Hu, Fung-Yin Ngo, Huiqi Zhang, Lin He, Hao Huang, Tan Wu, Yilin Pan, Zihan Yang, Yuanyuan Jiang, William C. Cho, Wah Cheuk, Gary M. Tse, Julia Y. Tsang, Mengsu Yang, Liang Zhang, Xin Wang, Pui-Chi Lo, C. Geoffrey Lau, Y. Rebecca Chin
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Triple-negative breast cancer
TUBB2B
Brain metastatic colonization
Protein translation
Online Access:https://doi.org/10.1186/s13046-025-03312-y
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