Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis
ABSTRACT Sex hormone‐binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review...
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2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14977 |
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| author | Ajay Malvi Muhammed Shabil Mahalaqua Nazli Khatib Roopashree R Mandeep Kaur Manish Srivastava Amit Barwal G. V. Siva Prasad Pranchal Rajput Rukshar Syed Kamal Kundra Vinamra Mittal Amit Kumar Pancham Cajla Ganesh Bushi Rachana Mehta Zaid Khan Prakasini Satapathy Shilpa Gaidhane Renu Sah |
| author_facet | Ajay Malvi Muhammed Shabil Mahalaqua Nazli Khatib Roopashree R Mandeep Kaur Manish Srivastava Amit Barwal G. V. Siva Prasad Pranchal Rajput Rukshar Syed Kamal Kundra Vinamra Mittal Amit Kumar Pancham Cajla Ganesh Bushi Rachana Mehta Zaid Khan Prakasini Satapathy Shilpa Gaidhane Renu Sah |
| author_sort | Ajay Malvi |
| collection | DOAJ |
| description | ABSTRACT Sex hormone‐binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta‐analysis explores the potential of SHBG as a biomarker for predicting GH and PE. A search of PubMed, Embase, and Web of Science was conducted to identify studies evaluating the association between SHBG levels and the risk of HDP, including GH and PE. Inclusion criteria encompassed observational studies reporting quantitative risk estimates (risk ratios, odds ratios, or hazard ratios) for SHBG levels. Results were pooled using a random‐effects meta‐analysis in R software (V 4.4), with the I2 statistic assessing heterogeneity. Eight studies were included in the systematic review from a total of 592 screened records. The association between SHBG levels and the risk of any HDP showed a pooled OR of 0.875 (95% CI: 0.772–0.993), for PE 0.890 (95% CI: 0.767–1.032), and for GH 0.729 (95% CI: 0.442–1.205), suggesting significant association between SHBG and HDP. Sensitivity analysis validated the robustness of the findings. This meta‐analysis found potential significant association between higher SHBG levels and risk of HDP. Further high‐quality research is required to better understand the role of SHBG in pregnancy‐related hypertensive disorders. Future studies should consider larger sample sizes, more precise measurement techniques, and explore potential confounding factors to clarify the potential utility of SHBG as a biomarker for predicting GH and PE. |
| format | Article |
| id | doaj-art-7fd88bf47b34456087e5e8218aee1f5c |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-7fd88bf47b34456087e5e8218aee1f5c2025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14977Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐AnalysisAjay Malvi0Muhammed Shabil1Mahalaqua Nazli Khatib2Roopashree R3Mandeep Kaur4Manish Srivastava5Amit Barwal6G. V. Siva Prasad7Pranchal Rajput8Rukshar Syed9Kamal Kundra10Vinamra Mittal11Amit Kumar12Pancham Cajla13Ganesh Bushi14Rachana Mehta15Zaid Khan16Prakasini Satapathy17Shilpa Gaidhane18Renu Sah19Department of Pharmacy Practice National Institute of Pharmaceutical Education and Research Guwahati IndiaNoida Institute of Engineering and Technology (Pharmacy Institute) Greater Noida IndiaDivision of Evidence Synthesis Global Consortium of Public Health and Research Datta Meghe Institute of Higher Education Wardha IndiaDepartment of Chemistry and Biochemistry School of Sciences JAIN (Deemed to be University) Bangalore Karnataka IndiaDepartment of Allied Healthcare and Sciences Vivekananda Global University Jaipur Rajasthan IndiaDepartment of Endocrinology NIMS University Jaipur IndiaChandigarh Pharmacy College Chandigarh Group of College, Jhanjeri Mohali Punjab IndiaDepartment of Chemistry Raghu Engineering College Visakhapatnam Andhra Pradesh IndiaSchool of Applied and Life Sciences Division of Research and Innovation Uttaranchal University Dehradun IndiaIES Institute of Pharmacy IES University Bhopal Madhya Pradesh IndiaNew Delhi Institute of Management, Tughlakabad Institutional Area New Delhi IndiaGraphic Era Institute of Medical Sciences Graphic Era (Deemed to be University), Clement Town Dehradun IndiaCentre of Research Impact and Outcome Chitkara University Rajpura Punjab IndiaChitkara Centre for Research and Development Chitkara University Pinjore Himachal Pradesh IndiaSchool of Pharmaceutical Sciences Lovely Professional University Phagwara IndiaClinical Microbiology RDC Manav Rachna International Institute of Research and Studies Faridabad Haryana IndiaCenter for Global Health Research Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai IndiaUniversity Center for Research and Development Chandigarh University Mohali Punjab IndiaOne Health Centre (COHERD) Jawaharlal Nehru Medical College Datta Meghe Institute of Higher Education Wardha IndiaSR Sanjeevani Hospital, Siraha Kalyanpur NepalABSTRACT Sex hormone‐binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta‐analysis explores the potential of SHBG as a biomarker for predicting GH and PE. A search of PubMed, Embase, and Web of Science was conducted to identify studies evaluating the association between SHBG levels and the risk of HDP, including GH and PE. Inclusion criteria encompassed observational studies reporting quantitative risk estimates (risk ratios, odds ratios, or hazard ratios) for SHBG levels. Results were pooled using a random‐effects meta‐analysis in R software (V 4.4), with the I2 statistic assessing heterogeneity. Eight studies were included in the systematic review from a total of 592 screened records. The association between SHBG levels and the risk of any HDP showed a pooled OR of 0.875 (95% CI: 0.772–0.993), for PE 0.890 (95% CI: 0.767–1.032), and for GH 0.729 (95% CI: 0.442–1.205), suggesting significant association between SHBG and HDP. Sensitivity analysis validated the robustness of the findings. This meta‐analysis found potential significant association between higher SHBG levels and risk of HDP. Further high‐quality research is required to better understand the role of SHBG in pregnancy‐related hypertensive disorders. Future studies should consider larger sample sizes, more precise measurement techniques, and explore potential confounding factors to clarify the potential utility of SHBG as a biomarker for predicting GH and PE.https://doi.org/10.1111/jch.14977gestational hypertensionhypertensive disorders of pregnancypreeclampsiapregnancy biomarkersex hormone binding globulin |
| spellingShingle | Ajay Malvi Muhammed Shabil Mahalaqua Nazli Khatib Roopashree R Mandeep Kaur Manish Srivastava Amit Barwal G. V. Siva Prasad Pranchal Rajput Rukshar Syed Kamal Kundra Vinamra Mittal Amit Kumar Pancham Cajla Ganesh Bushi Rachana Mehta Zaid Khan Prakasini Satapathy Shilpa Gaidhane Renu Sah Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis The Journal of Clinical Hypertension gestational hypertension hypertensive disorders of pregnancy preeclampsia pregnancy biomarker sex hormone binding globulin |
| title | Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis |
| title_full | Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis |
| title_fullStr | Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis |
| title_short | Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis |
| title_sort | association between shbg levels and hypertensive disorders of pregnancy a systematic review and meta analysis |
| topic | gestational hypertension hypertensive disorders of pregnancy preeclampsia pregnancy biomarker sex hormone binding globulin |
| url | https://doi.org/10.1111/jch.14977 |
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