Vitamin D and Its Role in Rheumatic Diseases
Vitamin D is a fat-soluble molecule with pleiotropic effects, acting as a steroid hormone on three main organs: the intestine, bone, and kidney. Among its best-known functions at the skeletal level are regulating bone metabolism and mineralization. In 1983, the presence of vitamin D receptors on the...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2218-1989/15/4/259 |
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| author | Maritza Vidal Nancy E. Lane |
| author_facet | Maritza Vidal Nancy E. Lane |
| author_sort | Maritza Vidal |
| collection | DOAJ |
| description | Vitamin D is a fat-soluble molecule with pleiotropic effects, acting as a steroid hormone on three main organs: the intestine, bone, and kidney. Among its best-known functions at the skeletal level are regulating bone metabolism and mineralization. In 1983, the presence of vitamin D receptors on the surface of immune cells was described, which led to the discovery of new functions on immunological and inflammatory processes. Currently, we know that vitamin D modulates the adaptative immune system by suppressing cells that produce inflammatory cytokines by downregulation, acting as an important regulator of immunity and the inflammatory response. In this article, we will review the synthesis, metabolic pathways, and the role of vitamin D in rheumatic autoimmune diseases. |
| format | Article |
| id | doaj-art-7fd3969d8f4f47ceab62b121abffc2c8 |
| institution | OA Journals |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-7fd3969d8f4f47ceab62b121abffc2c82025-08-20T02:18:14ZengMDPI AGMetabolites2218-19892025-04-0115425910.3390/metabo15040259Vitamin D and Its Role in Rheumatic DiseasesMaritza Vidal0Nancy E. Lane1Centro de Diagnóstico de Osteoporosis y Enfermedades Reumáticas (CEDOR), Lima 15036, PeruCenter for Musculoskeletal Health, University of California at Davis School of Medicine, Sacramento, CA 95817, USAVitamin D is a fat-soluble molecule with pleiotropic effects, acting as a steroid hormone on three main organs: the intestine, bone, and kidney. Among its best-known functions at the skeletal level are regulating bone metabolism and mineralization. In 1983, the presence of vitamin D receptors on the surface of immune cells was described, which led to the discovery of new functions on immunological and inflammatory processes. Currently, we know that vitamin D modulates the adaptative immune system by suppressing cells that produce inflammatory cytokines by downregulation, acting as an important regulator of immunity and the inflammatory response. In this article, we will review the synthesis, metabolic pathways, and the role of vitamin D in rheumatic autoimmune diseases.https://www.mdpi.com/2218-1989/15/4/259vitamin D25OHDcalcidiolcholecalciferolimmune systemrheumatic diseases |
| spellingShingle | Maritza Vidal Nancy E. Lane Vitamin D and Its Role in Rheumatic Diseases Metabolites vitamin D 25OHD calcidiol cholecalciferol immune system rheumatic diseases |
| title | Vitamin D and Its Role in Rheumatic Diseases |
| title_full | Vitamin D and Its Role in Rheumatic Diseases |
| title_fullStr | Vitamin D and Its Role in Rheumatic Diseases |
| title_full_unstemmed | Vitamin D and Its Role in Rheumatic Diseases |
| title_short | Vitamin D and Its Role in Rheumatic Diseases |
| title_sort | vitamin d and its role in rheumatic diseases |
| topic | vitamin D 25OHD calcidiol cholecalciferol immune system rheumatic diseases |
| url | https://www.mdpi.com/2218-1989/15/4/259 |
| work_keys_str_mv | AT maritzavidal vitamindanditsroleinrheumaticdiseases AT nancyelane vitamindanditsroleinrheumaticdiseases |