RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER
Patients with castration-refractory prostate cancer (PC) are a complicated group of patients for treatment. At the time of diagnosis, 85% of patients have a localized tumor process, however, in 40% of patients, generalization of the tumor process is observed. The most common localization of prostate...
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QUASAR, LLC
2017-12-01
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| Series: | Исследования и практика в медицине |
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| Online Access: | https://www.rpmj.ru/rpmj/article/view/223 |
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| author | A. A. Kostin A. G. Muradyan A. O. Tolkachev S. V. Popov |
| author_facet | A. A. Kostin A. G. Muradyan A. O. Tolkachev S. V. Popov |
| author_sort | A. A. Kostin |
| collection | DOAJ |
| description | Patients with castration-refractory prostate cancer (PC) are a complicated group of patients for treatment. At the time of diagnosis, 85% of patients have a localized tumor process, however, in 40% of patients, generalization of the tumor process is observed. The most common localization of prostate cancer metastasis is the skeletal bone, which affects up to 90% of cases.At the same time, taking into account the increase in the morbidity of prostate cancer pathology, it dictates the need to search for new, more effective methods of treatment for this group of patients. Currently, there are six effective methods of treatment of metastatic castration-refractory prostate cancer (mCRPC): effects on androgenic stimulation (abiraterone acetate, enzalutamide); chemotherapy with drugs from the taxane group (docetaxel, cabazitaxel); immunotherapy (Sipuleucel-T), radionuclide therapy with Radium-223 chloride (Ksofigo®). 223Ra is a tropic to bone tissue alpha emitter, which, due to its high linear energy transfer and short transmission distance, provides an enhanced localized antitumor effect due to higher energy delivery. The article presents a literature review highlighting the mechanisms of development of castration refractoriness, the characteristic and efficacy of Radium-223 in the treatment of patients with metastatic castration-refractory prostate cancer. |
| format | Article |
| id | doaj-art-7fbd8f27d5934e7982cfe8046f418487 |
| institution | Kabale University |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2017-12-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-7fbd8f27d5934e7982cfe8046f4184872025-02-03T00:57:40ZrusQUASAR, LLCИсследования и практика в медицине2410-18932017-12-0144798810.17709/2409-2231-2017-4-4-9173RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCERA. A. Kostin0A. G. Muradyan1A. O. Tolkachev2S. V. Popov3National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation; Medical Institute of Peoples Friendship University of RussiaMedical Institute of Peoples Friendship University of Russia; P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Radiology Research Centre of the Ministry of Health of the Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Radiology Research Centre of the Ministry of Health of the Russian FederationNational Medical Radiology Research Centre of the Ministry of Health of the Russian FederationPatients with castration-refractory prostate cancer (PC) are a complicated group of patients for treatment. At the time of diagnosis, 85% of patients have a localized tumor process, however, in 40% of patients, generalization of the tumor process is observed. The most common localization of prostate cancer metastasis is the skeletal bone, which affects up to 90% of cases.At the same time, taking into account the increase in the morbidity of prostate cancer pathology, it dictates the need to search for new, more effective methods of treatment for this group of patients. Currently, there are six effective methods of treatment of metastatic castration-refractory prostate cancer (mCRPC): effects on androgenic stimulation (abiraterone acetate, enzalutamide); chemotherapy with drugs from the taxane group (docetaxel, cabazitaxel); immunotherapy (Sipuleucel-T), radionuclide therapy with Radium-223 chloride (Ksofigo®). 223Ra is a tropic to bone tissue alpha emitter, which, due to its high linear energy transfer and short transmission distance, provides an enhanced localized antitumor effect due to higher energy delivery. The article presents a literature review highlighting the mechanisms of development of castration refractoriness, the characteristic and efficacy of Radium-223 in the treatment of patients with metastatic castration-refractory prostate cancer.https://www.rpmj.ru/rpmj/article/view/223prostate cancerpccastration-refractorymcrpcradium-223ksofigohormoneresistence |
| spellingShingle | A. A. Kostin A. G. Muradyan A. O. Tolkachev S. V. Popov RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER Исследования и практика в медицине prostate cancer pc castration-refractory mcrpc radium-223 ksofigo hormoneresistence |
| title | RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER |
| title_full | RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER |
| title_fullStr | RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER |
| title_full_unstemmed | RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER |
| title_short | RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER |
| title_sort | radium 223 place in the treatment of metastatic castration refractory prostate cancer |
| topic | prostate cancer pc castration-refractory mcrpc radium-223 ksofigo hormoneresistence |
| url | https://www.rpmj.ru/rpmj/article/view/223 |
| work_keys_str_mv | AT aakostin radium223placeinthetreatmentofmetastaticcastrationrefractoryprostatecancer AT agmuradyan radium223placeinthetreatmentofmetastaticcastrationrefractoryprostatecancer AT aotolkachev radium223placeinthetreatmentofmetastaticcastrationrefractoryprostatecancer AT svpopov radium223placeinthetreatmentofmetastaticcastrationrefractoryprostatecancer |