Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable?
Introduction: Systemic targeted therapy options are commonly used in patients with metastatic renal cell carcinoma (mRCC). Histological verification is crucial for treatment of mRCC. Aim: Our aim was to evaluate an optimal location for percutaneous computed tomography-guided biopsy in a diagnosis...
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Termedia Publishing House
2024-07-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
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| Online Access: | https://www.mp.pl/videosurgery/issue/article/17894/ |
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| author | Petr Hoffmann Michal Balik Martina Hoffmannova Jindrich Kopecky Pavel Ryska Jana Draganovicova Petr Dvorak |
| author_facet | Petr Hoffmann Michal Balik Martina Hoffmannova Jindrich Kopecky Pavel Ryska Jana Draganovicova Petr Dvorak |
| author_sort | Petr Hoffmann |
| collection | DOAJ |
| description | Introduction: Systemic targeted therapy options are commonly used in patients with metastatic renal cell carcinoma (mRCC). Histological verification is crucial for treatment of mRCC.
Aim: Our aim was to evaluate an optimal location for percutaneous computed tomography-guided biopsy in a diagnosis of suspected mRCC.
Materials and methods: A total of 138 percutaneous biopsies for tumors ranging from 21 to 133 mm in diameter (median, 72 mm) were carried out in 134 patients with suspected mRCC over a 5-year period. The biopsy location was variable, with kidney biopsy performed in 77 cases (55.8%), and other localizations (retroperitoneum, peritoneal cavity, liver, pelvis, pleural space, lung, mediastinum, chest or abdominal wall, and pancreas) in 61 cases (44.2%).
Results: As many as 288 biopsies (97.1%), yielded true-positive results, and 4 procedures (2.9%) yielded histologically false-negative results that required confirmation through extended rebiopsy. RCC was the most common individual diagnosis (85.5%), with non-RCC histology verified in 14.5% of cases. In total, 32 complications (23.2%) were confirmed, 2 of which were pneumothoraces, 29 were minor bleeding that needed only conservative management, and 1 case required angiography and embolization for hemorrhage treatment. While no significant relationship between the biopsy success and lesion localization (renal vs other) was found (P = 0.13), the relationship between complication rate and biopsy localization (renal vs other) was significant (P = 0.01).
Conclusions: Lesion localization (renal vs other) was not relevant to histological accuracy of the biopsies performed in patients with suspected mRCC. However, the biopsies of lesions outside the kidney had a lower complication rate. |
| format | Article |
| id | doaj-art-7fa92c8b6db541fe975d4ac593644549 |
| institution | Kabale University |
| issn | 1895-4588 2299-0054 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Termedia Publishing House |
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| series | Videosurgery and Other Miniinvasive Techniques |
| spelling | doaj-art-7fa92c8b6db541fe975d4ac5936445492025-01-29T17:35:01ZengTermedia Publishing HouseVideosurgery and Other Miniinvasive Techniques1895-45882299-00542024-07-0119336136910.20452/wiitm.2024.17894Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable?Petr Hoffmann0Michal Balik1Martina Hoffmannova2Jindrich Kopecky3Pavel Ryska4Jana Draganovicova5Petr Dvorak6Department of Radiology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech RepublicDepartment of Urology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech RepublicFaculty of Education, Charles University, Prague, Czech RepublicDepartment of Oncology and Radiotherapy, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech RepublicDepartment of Radiology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech RepublicDepartment of Radiology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech RepublicDepartment of Radiology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech RepublicIntroduction: Systemic targeted therapy options are commonly used in patients with metastatic renal cell carcinoma (mRCC). Histological verification is crucial for treatment of mRCC. Aim: Our aim was to evaluate an optimal location for percutaneous computed tomography-guided biopsy in a diagnosis of suspected mRCC. Materials and methods: A total of 138 percutaneous biopsies for tumors ranging from 21 to 133 mm in diameter (median, 72 mm) were carried out in 134 patients with suspected mRCC over a 5-year period. The biopsy location was variable, with kidney biopsy performed in 77 cases (55.8%), and other localizations (retroperitoneum, peritoneal cavity, liver, pelvis, pleural space, lung, mediastinum, chest or abdominal wall, and pancreas) in 61 cases (44.2%). Results: As many as 288 biopsies (97.1%), yielded true-positive results, and 4 procedures (2.9%) yielded histologically false-negative results that required confirmation through extended rebiopsy. RCC was the most common individual diagnosis (85.5%), with non-RCC histology verified in 14.5% of cases. In total, 32 complications (23.2%) were confirmed, 2 of which were pneumothoraces, 29 were minor bleeding that needed only conservative management, and 1 case required angiography and embolization for hemorrhage treatment. While no significant relationship between the biopsy success and lesion localization (renal vs other) was found (P = 0.13), the relationship between complication rate and biopsy localization (renal vs other) was significant (P = 0.01). Conclusions: Lesion localization (renal vs other) was not relevant to histological accuracy of the biopsies performed in patients with suspected mRCC. However, the biopsies of lesions outside the kidney had a lower complication rate.https://www.mp.pl/videosurgery/issue/article/17894/biopsy locationcomplication ratecomputed tomography guidancemetastatic diseaserenal cell carcinoma |
| spellingShingle | Petr Hoffmann Michal Balik Martina Hoffmannova Jindrich Kopecky Pavel Ryska Jana Draganovicova Petr Dvorak Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? Videosurgery and Other Miniinvasive Techniques biopsy location complication rate computed tomography guidance metastatic disease renal cell carcinoma |
| title | Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? |
| title_full | Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? |
| title_fullStr | Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? |
| title_full_unstemmed | Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? |
| title_short | Computed tomography–guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma: which location is the most suitable? |
| title_sort | computed tomography guided percutaneous biopsy in diagnosis of suspected metastatic renal cell carcinoma which location is the most suitable |
| topic | biopsy location complication rate computed tomography guidance metastatic disease renal cell carcinoma |
| url | https://www.mp.pl/videosurgery/issue/article/17894/ |
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