Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

BackgroundAlzheimer’s disease (AD) is marked by the pathological features of amyloid-β plaque accumulation, as well as intracellular neurofibrillary tangles formation in the patients’ brain. Aberrant lipid metabolism is increasingly recognized as one of the important contributors to AD.PurposeThe ma...

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Bibliographic Details
Main Authors: Shiyu Xiao, Xuemeng Wei, Bing Han, Xiaoqian Shi, Congzhen Wei, Rumeng Liang, Jingna Sun, Zheng Zhang, Zhengang Han, Li Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
APP/PS1 mice
hippocampus
targeted lipidomics
UHPLC-MS
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1561831/full
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