Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study
Introduction Despite strong and consistent epidemiological evidence linking cigarette smoking to several cardiovascular diseases (CVDs), the association between smoking intensity and CVD risk factors remains unclear. This study aimed to explore the possible effects of cigarette smoking on cardiometa...
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| Format: | Article |
| Language: | English |
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European Publishing
2024-07-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Association-of-cigarette-smoking-with-cardiometabolic-risk-factors-A-cross-sectional,191246,0,2.html |
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| _version_ | 1832587226260701184 |
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| author | Samar Sultan Fouzy Lesloom |
| author_facet | Samar Sultan Fouzy Lesloom |
| author_sort | Samar Sultan |
| collection | DOAJ |
| description | Introduction
Despite strong and consistent epidemiological evidence linking
cigarette smoking to several cardiovascular diseases (CVDs), the association
between smoking intensity and CVD risk factors remains unclear. This study
aimed to explore the possible effects of cigarette smoking on cardiometabolic
risk in healthy individuals.
Methods
This cross-sectional study was conducted between November 2022
and June 2023. Consecutive sampling was performed to include 160 healthy
participants: 100 smokers with 60 males and 40 females; and 60 age- and sexmatched
non-smokers with 36 males and 24 females. Blood samples were taken
from each participant to assess their cardiometabolic function: lipid profile, von
Willebrand factor (vWF), high-sensitivity cardiac troponin I (hs-cTnI), and
fibrinogen levels; and liver function using an automated enzymatic method. In
addition, blood sugar level, body mass index (BMI), and blood pressure were
recorded.
Results
Smokers had significantly higher vWF functional activity and hs-cTnI but
significantly lower albumin and total bilirubin levels than non-smokers (65.87 ±
19.07 vs 56.45 ± 6.59, respectively, p<0.001; 0.0382 ± 0.0077 vs 0.0147 ± 0.0105,
respectively, p<0.001; and 4.63 ± 0.32 vs 4.74 ± 0.28, respectively, p=0.026). The
number of cigarettes consumed daily was associated positively and significantly
with plasma levels of low-density lipoprotein cholesterol, high-density lipoprotein
cholesterol, vWF functional activity, and hs-cTnI but were negatively associated
with total bilirubin. Moreover, heavy smokers had a significantly higher BMI and
waist-to-hip ratio among male smokers than non-smokers.
Conclusions
Cigarette smoking was associated with increased dyslipidemia, BMI,
and central obesity, in addition to higher vWF functional activity. Altogether,
increased hs-cTnI levels in smokers indicate a higher susceptibility to CVD. |
| format | Article |
| id | doaj-art-7f9c9e8dcf02483a9104b1fbefa51012 |
| institution | Kabale University |
| issn | 1617-9625 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj-art-7f9c9e8dcf02483a9104b1fbefa510122025-01-24T15:27:00ZengEuropean PublishingTobacco Induced Diseases1617-96252024-07-0122July11010.18332/tid/191246191246Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional studySamar Sultan0Fouzy Lesloom1Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaMedical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaIntroduction Despite strong and consistent epidemiological evidence linking cigarette smoking to several cardiovascular diseases (CVDs), the association between smoking intensity and CVD risk factors remains unclear. This study aimed to explore the possible effects of cigarette smoking on cardiometabolic risk in healthy individuals. Methods This cross-sectional study was conducted between November 2022 and June 2023. Consecutive sampling was performed to include 160 healthy participants: 100 smokers with 60 males and 40 females; and 60 age- and sexmatched non-smokers with 36 males and 24 females. Blood samples were taken from each participant to assess their cardiometabolic function: lipid profile, von Willebrand factor (vWF), high-sensitivity cardiac troponin I (hs-cTnI), and fibrinogen levels; and liver function using an automated enzymatic method. In addition, blood sugar level, body mass index (BMI), and blood pressure were recorded. Results Smokers had significantly higher vWF functional activity and hs-cTnI but significantly lower albumin and total bilirubin levels than non-smokers (65.87 ± 19.07 vs 56.45 ± 6.59, respectively, p<0.001; 0.0382 ± 0.0077 vs 0.0147 ± 0.0105, respectively, p<0.001; and 4.63 ± 0.32 vs 4.74 ± 0.28, respectively, p=0.026). The number of cigarettes consumed daily was associated positively and significantly with plasma levels of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, vWF functional activity, and hs-cTnI but were negatively associated with total bilirubin. Moreover, heavy smokers had a significantly higher BMI and waist-to-hip ratio among male smokers than non-smokers. Conclusions Cigarette smoking was associated with increased dyslipidemia, BMI, and central obesity, in addition to higher vWF functional activity. Altogether, increased hs-cTnI levels in smokers indicate a higher susceptibility to CVD.https://www.tobaccoinduceddiseases.org/Association-of-cigarette-smoking-with-cardiometabolic-risk-factors-A-cross-sectional,191246,0,2.htmlsmokingcardiometabolic risk factorsliver function testshigh-sensitivity cardiac troponin i |
| spellingShingle | Samar Sultan Fouzy Lesloom Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study Tobacco Induced Diseases smoking cardiometabolic risk factors liver function tests high-sensitivity cardiac troponin i |
| title | Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study |
| title_full | Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study |
| title_fullStr | Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study |
| title_full_unstemmed | Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study |
| title_short | Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study |
| title_sort | association of cigarette smoking with cardiometabolic risk factors a cross sectional study |
| topic | smoking cardiometabolic risk factors liver function tests high-sensitivity cardiac troponin i |
| url | https://www.tobaccoinduceddiseases.org/Association-of-cigarette-smoking-with-cardiometabolic-risk-factors-A-cross-sectional,191246,0,2.html |
| work_keys_str_mv | AT samarsultan associationofcigarettesmokingwithcardiometabolicriskfactorsacrosssectionalstudy AT fouzylesloom associationofcigarettesmokingwithcardiometabolicriskfactorsacrosssectionalstudy |