Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe3O4 magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/127835 |
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| author | Malihe Khoeini Sharifabadi Mohammad Saber-Tehrani Syed Waqif Husain Ali Mehdinia Parviz Aberoomand-Azar |
| author_facet | Malihe Khoeini Sharifabadi Mohammad Saber-Tehrani Syed Waqif Husain Ali Mehdinia Parviz Aberoomand-Azar |
| author_sort | Malihe Khoeini Sharifabadi |
| collection | DOAJ |
| description | A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe3O4 magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed. For this purpose, the surface of MNPs was modified with cetyltrimethylammonium bromide (CTAB) as a cationic surfactant. Effects of different parameters influencing the extraction efficiency of drugs including the pH, amount of salt, shaking time, eluent type, the volume of solvent, amount of adsorbent, sample volume, and the time of desorption were investigated and optimized. Methanol has been used as desorption solvent and the extracts were analysed on a reversed-phase octadecyl silica column using 0.02 M phosphate-buffer (pH = 6.02) acetonitrile (65 : 35 v/v) as the mobile phase and the effluents were measured at 202 nm with ultraviolet detector. The relative standard deviation (RSD%) of the method was investigated at three concentrations (25, 50, and 200 ng/mL) and was in the range of 3.98–9.83% (n=6) for 50 ng/mL. The calibration curves obtained for studied drugs show reasonable linearity (R2>0.99) and the limit of detection (LODs) ranged between 2 and 7 ng/mL. Finally, the proposed method has been effectively employed in extraction and determination of the drugs in biological and environmental samples. |
| format | Article |
| id | doaj-art-7f9a1ccd6bf44f8a8826160bab35c54b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7f9a1ccd6bf44f8a8826160bab35c54b2025-02-03T01:31:03ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/127835127835Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid ChromatographyMalihe Khoeini Sharifabadi0Mohammad Saber-Tehrani1Syed Waqif Husain2Ali Mehdinia3Parviz Aberoomand-Azar4Department of Chemistry, Science and Research Branch, Islamic Azad University, Poonak Hesarak, Tehran, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Poonak Hesarak, Tehran, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Poonak Hesarak, Tehran, IranDepartment of Marine Science, Iranian National Institute for Oceanography, Tehran, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Poonak Hesarak, Tehran, IranA simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe3O4 magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed. For this purpose, the surface of MNPs was modified with cetyltrimethylammonium bromide (CTAB) as a cationic surfactant. Effects of different parameters influencing the extraction efficiency of drugs including the pH, amount of salt, shaking time, eluent type, the volume of solvent, amount of adsorbent, sample volume, and the time of desorption were investigated and optimized. Methanol has been used as desorption solvent and the extracts were analysed on a reversed-phase octadecyl silica column using 0.02 M phosphate-buffer (pH = 6.02) acetonitrile (65 : 35 v/v) as the mobile phase and the effluents were measured at 202 nm with ultraviolet detector. The relative standard deviation (RSD%) of the method was investigated at three concentrations (25, 50, and 200 ng/mL) and was in the range of 3.98–9.83% (n=6) for 50 ng/mL. The calibration curves obtained for studied drugs show reasonable linearity (R2>0.99) and the limit of detection (LODs) ranged between 2 and 7 ng/mL. Finally, the proposed method has been effectively employed in extraction and determination of the drugs in biological and environmental samples.http://dx.doi.org/10.1155/2014/127835 |
| spellingShingle | Malihe Khoeini Sharifabadi Mohammad Saber-Tehrani Syed Waqif Husain Ali Mehdinia Parviz Aberoomand-Azar Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography The Scientific World Journal |
| title | Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography |
| title_full | Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography |
| title_fullStr | Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography |
| title_full_unstemmed | Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography |
| title_short | Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography |
| title_sort | determination of residual nonsteroidal anti inflammatory drugs in aqueous sample using magnetic nanoparticles modified with cetyltrimethylammonium bromide by high performance liquid chromatography |
| url | http://dx.doi.org/10.1155/2014/127835 |
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