T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives
Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients. In the last decades, the identification of a number of T cell subsets, including Th17, T...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/243723 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554226837880832 |
|---|---|
| author | Alessia Alunno Francesco Carubbi Onelia Bistoni Sara Caterbi Elena Bartoloni Giulia Mirabelli Francesca Cannarile Paola Cipriani Roberto Giacomelli Roberto Gerli |
| author_facet | Alessia Alunno Francesco Carubbi Onelia Bistoni Sara Caterbi Elena Bartoloni Giulia Mirabelli Francesca Cannarile Paola Cipriani Roberto Giacomelli Roberto Gerli |
| author_sort | Alessia Alunno |
| collection | DOAJ |
| description | Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients. In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis. In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention. However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated. In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis. We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease. |
| format | Article |
| id | doaj-art-7f7830476cd44176bc83e71510733672 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7f7830476cd44176bc83e715107336722025-02-03T05:52:00ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/243723243723T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and PerspectivesAlessia Alunno0Francesco Carubbi1Onelia Bistoni2Sara Caterbi3Elena Bartoloni4Giulia Mirabelli5Francesca Cannarile6Paola Cipriani7Roberto Giacomelli8Roberto Gerli9Rheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyRheumatology Unit, Department of Medicine, University of Perugia, 06123 Perugia, ItalyHistorically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients. In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis. In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention. However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated. In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis. We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.http://dx.doi.org/10.1155/2015/243723 |
| spellingShingle | Alessia Alunno Francesco Carubbi Onelia Bistoni Sara Caterbi Elena Bartoloni Giulia Mirabelli Francesca Cannarile Paola Cipriani Roberto Giacomelli Roberto Gerli T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives Mediators of Inflammation |
| title | T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives |
| title_full | T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives |
| title_fullStr | T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives |
| title_full_unstemmed | T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives |
| title_short | T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives |
| title_sort | t regulatory and t helper 17 cells in primary sjogren s syndrome facts and perspectives |
| url | http://dx.doi.org/10.1155/2015/243723 |
| work_keys_str_mv | AT alessiaalunno tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT francescocarubbi tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT oneliabistoni tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT saracaterbi tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT elenabartoloni tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT giuliamirabelli tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT francescacannarile tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT paolacipriani tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT robertogiacomelli tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives AT robertogerli tregulatoryandthelper17cellsinprimarysjogrenssyndromefactsandperspectives |