DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model

DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model

Oligonucleotide aptamers are typically identified through a rigorous and time-consuming process known as systematic evolution of ligands by exponential enrichment (SELEX), which requires 20 to 30 iterative rounds to eliminate non/weak binding sequences and enrich tight binding sequences with high af...

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Bibliographic Details
Main Authors: Xin Yang, Chi Ho Chan, Shanshan Yao, Hang Yin Chu, Minchuan Lyu, Ziqi Chen, Huan Xiao, Yuan Ma, Sifan Yu, Fangfei Li, Jin Liu, Luyao Wang, Zongkang Zhang, Bao-Ting Zhang, Lu Zhang, Aiping Lu, Yaofeng Wang, Ge Zhang, Yuanyuan Yu
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
aptamers
SELEX
DNA sequence
DNA shape features
hybrid neural network
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124003238
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