RNA structure in alternative splicing regulation: from mechanism to therapy
Alternative splicing is a highly intricate process that plays a crucial role in post-transcriptional regulation and significantly expands the functional proteome of a limited number of coding genes in eukaryotes. Its regulation is multifact...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-07-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024119 |
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| _version_ | 1832590338349334528 |
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| author | Bao Nengcheng Wang Zhechao Fu Jiayan Dong Haiyang Jin Yongfeng |
| author_facet | Bao Nengcheng Wang Zhechao Fu Jiayan Dong Haiyang Jin Yongfeng |
| author_sort | Bao Nengcheng |
| collection | DOAJ |
| description | Alternative splicing is a highly intricate process that plays a crucial role in post-transcriptional regulation and significantly expands the functional proteome of a limited number of coding genes in eukaryotes. Its regulation is multifactorial, with RNA structure exerting a significant impact. Aberrant RNA conformations lead to dysregulation of splicing patterns, which directly affects the manifestation of disease symptoms. In this review, the molecular mechanisms of RNA secondary structure-mediated splicing regulation are summarized, with a focus on the complex interplay between aberrant RNA conformations and disease phenotypes resulted from splicing defects. This study also explores additional factors that reshape structural conformations, enriching our understanding of the mechanistic network underlying structure-mediated splicing regulation. In addition, an emphasis has been placed on the clinical role of targeting aberrant splicing corrections in human diseases. The principal mechanisms of action behind this phenomenon are described, followed by a discussion of prospective development strategies and pertinent challenges. |
| format | Article |
| id | doaj-art-7f68280d79f643ac9713e3e7ad44f718 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-7f68280d79f643ac9713e3e7ad44f7182025-01-24T00:56:44ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-07-015732110.3724/abbs.202411920d259ccRNA structure in alternative splicing regulation: from mechanism to therapyBao Nengcheng0Wang Zhechao1Fu Jiayan2Dong Haiyang3Jin Yongfeng4[][][][][]Alternative splicing is a highly intricate process that plays a crucial role in post-transcriptional regulation and significantly expands the functional proteome of a limited number of coding genes in eukaryotes. Its regulation is multifactorial, with RNA structure exerting a significant impact. Aberrant RNA conformations lead to dysregulation of splicing patterns, which directly affects the manifestation of disease symptoms. In this review, the molecular mechanisms of RNA secondary structure-mediated splicing regulation are summarized, with a focus on the complex interplay between aberrant RNA conformations and disease phenotypes resulted from splicing defects. This study also explores additional factors that reshape structural conformations, enriching our understanding of the mechanistic network underlying structure-mediated splicing regulation. In addition, an emphasis has been placed on the clinical role of targeting aberrant splicing corrections in human diseases. The principal mechanisms of action behind this phenomenon are described, followed by a discussion of prospective development strategies and pertinent challenges.https://www.sciengine.com/doi/10.3724/abbs.2024119aberrant splicingantisense oligonucleotides (ASOs)RNA secondary structureRNA-targeted therapysplicing regulation |
| spellingShingle | Bao Nengcheng Wang Zhechao Fu Jiayan Dong Haiyang Jin Yongfeng RNA structure in alternative splicing regulation: from mechanism to therapy Acta Biochimica et Biophysica Sinica aberrant splicing antisense oligonucleotides (ASOs) RNA secondary structure RNA-targeted therapy splicing regulation |
| title | RNA structure in alternative splicing regulation: from mechanism to therapy |
| title_full | RNA structure in alternative splicing regulation: from mechanism to therapy |
| title_fullStr | RNA structure in alternative splicing regulation: from mechanism to therapy |
| title_full_unstemmed | RNA structure in alternative splicing regulation: from mechanism to therapy |
| title_short | RNA structure in alternative splicing regulation: from mechanism to therapy |
| title_sort | rna structure in alternative splicing regulation from mechanism to therapy |
| topic | aberrant splicing antisense oligonucleotides (ASOs) RNA secondary structure RNA-targeted therapy splicing regulation |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024119 |
| work_keys_str_mv | AT baonengcheng rnastructureinalternativesplicingregulationfrommechanismtotherapy AT wangzhechao rnastructureinalternativesplicingregulationfrommechanismtotherapy AT fujiayan rnastructureinalternativesplicingregulationfrommechanismtotherapy AT donghaiyang rnastructureinalternativesplicingregulationfrommechanismtotherapy AT jinyongfeng rnastructureinalternativesplicingregulationfrommechanismtotherapy |