When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report
Severe infections that develop rapidly from ordinary symptoms not only increase patient misunderstandings but also lead to excessive detection of these symptoms by physicians. This case study describes a 19-year-old male individual who initially presented with a sore throat and subsequently develope...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1517389/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582956377440256 |
|---|---|
| author | Fangqi Zhang Juan-Li Wang Jian Zhu Shaokui Si Hao Guo Xiang Yue Wei Wen |
| author_facet | Fangqi Zhang Juan-Li Wang Jian Zhu Shaokui Si Hao Guo Xiang Yue Wei Wen |
| author_sort | Fangqi Zhang |
| collection | DOAJ |
| description | Severe infections that develop rapidly from ordinary symptoms not only increase patient misunderstandings but also lead to excessive detection of these symptoms by physicians. This case study describes a 19-year-old male individual who initially presented with a sore throat and subsequently developed multiple serous cavity effusions that lead to septic pulmonary embolism and septic shock. After multiple cultures of the patient’s sputum yielded no identifiable pathogenic bacteria, the metagenomic next-generation sequencing (mNGS) revealed Prevotella oris as the predominant pathogen present in both the patient’s peripheral blood and the pericardial drainage fluid. The subsequent antibiotic treatment, guided by the mNGS results, along with surgical drainage and mediastinal irrigation, effectively controlled and ultimately cured the patient’s condition. This case is unique because it is the first to show that normally colonizing Prevotella can also cause fatal multiorgan infection as an opportunistic pathogen in a previously healthy young person with no immune-related diseases. The aim of this study is to expand clinical awareness of this common symptom and its potentially fatal outcome. |
| format | Article |
| id | doaj-art-7f5c475f80844956a8f77092a7b645d9 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-7f5c475f80844956a8f77092a7b645d92025-01-29T05:21:33ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15173891517389When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case reportFangqi Zhang0Juan-Li Wang1Jian Zhu2Shaokui Si3Hao Guo4Xiang Yue5Wei Wen6Department of Pulmonary and Critical Care Medicine, The 987th Hospital of Joint Logistics Support Force of People's Liberation Army, Baoji, ChinaDepartment of Child Healthcare, The Third Hospital of Wuhan, Wuhan, ChinaDepartment of Thyroid and Breast Surgery, General Hospital of Central Theater Command of the People's Liberation Army, Wuhan, ChinaDepartment of Pulmonary and Critical Care Medicine, The 987th Hospital of Joint Logistics Support Force of People's Liberation Army, Baoji, ChinaDepartment of Thoracic Cardiovascular Surgery, The 987th Hospital of Joint Logistics Support Force of People's Liberation Army, Baoji, ChinaDepartment of Thoracic Cardiovascular Surgery, The 987th Hospital of Joint Logistics Support Force of People's Liberation Army, Baoji, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaSevere infections that develop rapidly from ordinary symptoms not only increase patient misunderstandings but also lead to excessive detection of these symptoms by physicians. This case study describes a 19-year-old male individual who initially presented with a sore throat and subsequently developed multiple serous cavity effusions that lead to septic pulmonary embolism and septic shock. After multiple cultures of the patient’s sputum yielded no identifiable pathogenic bacteria, the metagenomic next-generation sequencing (mNGS) revealed Prevotella oris as the predominant pathogen present in both the patient’s peripheral blood and the pericardial drainage fluid. The subsequent antibiotic treatment, guided by the mNGS results, along with surgical drainage and mediastinal irrigation, effectively controlled and ultimately cured the patient’s condition. This case is unique because it is the first to show that normally colonizing Prevotella can also cause fatal multiorgan infection as an opportunistic pathogen in a previously healthy young person with no immune-related diseases. The aim of this study is to expand clinical awareness of this common symptom and its potentially fatal outcome.https://www.frontiersin.org/articles/10.3389/fmed.2025.1517389/fullpolyserous effusionsPrevotellasore throatnecrotizing mediastinitiscase report |
| spellingShingle | Fangqi Zhang Juan-Li Wang Jian Zhu Shaokui Si Hao Guo Xiang Yue Wei Wen When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report Frontiers in Medicine polyserous effusions Prevotella sore throat necrotizing mediastinitis case report |
| title | When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report |
| title_full | When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report |
| title_fullStr | When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report |
| title_full_unstemmed | When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report |
| title_short | When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report |
| title_sort | when a sore throat turns into deadly multiple serous cavity effusions the role of prevotella oris in rapidly progressing infection a case report |
| topic | polyserous effusions Prevotella sore throat necrotizing mediastinitis case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1517389/full |
| work_keys_str_mv | AT fangqizhang whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport AT juanliwang whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport AT jianzhu whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport AT shaokuisi whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport AT haoguo whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport AT xiangyue whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport AT weiwen whenasorethroatturnsintodeadlymultipleserouscavityeffusionstheroleofprevotellaorisinrapidlyprogressinginfectionacasereport |