Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases
Aims. Liver metastases occur in approximately 25% of colorectal cancer (CRC) patients and cause more than 90% of deaths in CRC. Platelets play a crucial role in cancer progression and metastases. We aimed to investigate the relationship between platelet indices and CRC with synchronous liver metasta...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/6397513 |
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| _version_ | 1832560252714745856 |
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| author | Li Li Xiao-Yi Huang Na Li Ming-ming Cui Rui-tao Wang |
| author_facet | Li Li Xiao-Yi Huang Na Li Ming-ming Cui Rui-tao Wang |
| author_sort | Li Li |
| collection | DOAJ |
| description | Aims. Liver metastases occur in approximately 25% of colorectal cancer (CRC) patients and cause more than 90% of deaths in CRC. Platelets play a crucial role in cancer progression and metastases. We aimed to investigate the relationship between platelet indices and CRC with synchronous liver metastases. Methods. We conducted a retrospective clinical study including 206 CRC patients without metastases and 200 CRC patients with synchronous liver metastases from January 1, 2015, to December 31, 2017. Data of the patients’ clinicopathological characteristics were collected. Results. Platelet distribution width (PDW) was decreased in CRC patients with liver metastases compared with CRC patients without liver metastases. In addition, the prevalence of liver metastases reduced as PDW quartiles increased. After adjusting for other risk factors, the odds ratios (95% confidence intervals) for CRC liver metastases according to PDW quartiles were 1.000, 0.289 (0.156-0.535), 0.482 (0.271-0.860), and 0.190 (0.101-0.358). Conclusions. Compared with CRC patients without metastases, PDW is reduced in CRC patients with liver metastases. Moreover, PDW was independently associated with the presence of CRC liver metastases. |
| format | Article |
| id | doaj-art-7f514d2cc9c74e988a14a73581cb5679 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-7f514d2cc9c74e988a14a73581cb56792025-02-03T01:28:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/63975136397513Platelet Indices in Colorectal Cancer Patients with Synchronous Liver MetastasesLi Li0Xiao-Yi Huang1Na Li2Ming-ming Cui3Rui-tao Wang4Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaBiotherapy Center, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaAims. Liver metastases occur in approximately 25% of colorectal cancer (CRC) patients and cause more than 90% of deaths in CRC. Platelets play a crucial role in cancer progression and metastases. We aimed to investigate the relationship between platelet indices and CRC with synchronous liver metastases. Methods. We conducted a retrospective clinical study including 206 CRC patients without metastases and 200 CRC patients with synchronous liver metastases from January 1, 2015, to December 31, 2017. Data of the patients’ clinicopathological characteristics were collected. Results. Platelet distribution width (PDW) was decreased in CRC patients with liver metastases compared with CRC patients without liver metastases. In addition, the prevalence of liver metastases reduced as PDW quartiles increased. After adjusting for other risk factors, the odds ratios (95% confidence intervals) for CRC liver metastases according to PDW quartiles were 1.000, 0.289 (0.156-0.535), 0.482 (0.271-0.860), and 0.190 (0.101-0.358). Conclusions. Compared with CRC patients without metastases, PDW is reduced in CRC patients with liver metastases. Moreover, PDW was independently associated with the presence of CRC liver metastases.http://dx.doi.org/10.1155/2019/6397513 |
| spellingShingle | Li Li Xiao-Yi Huang Na Li Ming-ming Cui Rui-tao Wang Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases Gastroenterology Research and Practice |
| title | Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases |
| title_full | Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases |
| title_fullStr | Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases |
| title_full_unstemmed | Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases |
| title_short | Platelet Indices in Colorectal Cancer Patients with Synchronous Liver Metastases |
| title_sort | platelet indices in colorectal cancer patients with synchronous liver metastases |
| url | http://dx.doi.org/10.1155/2019/6397513 |
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